{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:20:46Z","timestamp":1792628446012,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to evaluate the ototoxicity of topical oxiconazole and boric acid in alcohol solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective controlled animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Research laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty adult Wistar albino rats were divided into 5\u00a0groups consisting of 10 animals each. The right tympanic membranes were perforated, and baseline and posttreatment distortion product otoacoustic emission (DPOAE) measurements were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The solutions were applied through the external ear canal to the middle ear twice a day for 14\u00a0days. The rats in group I and group II received 0.1\u00a0mL of oxiconazole\u2010containing solution drops and 4% boric acid in alcohol solution drops, respectively. Group III received gentamicin solution (40\u00a0mg\/mL) (ototoxic control), group IV received saline solution, and group V was followed without any medication. The baseline DPOAE results of the right ears of all animals tested were normal. Animals in groups I, II, IV, and V showed no statistically significant change in the DPOAE amplitudes. The rats in the gentamicin group showed a significant decrease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that topically used oxiconazole and boric acid in alcohol solutions to the middle ear appear to be safe on the inner ear of rats. The safety of these drugs has not yet been confirmed in humans. Caution should be taken when prescribing these drugs, especially to patients who had tympanic membrane perforation. Ear drops should be chosen more carefully in an external ear infection for patients with tympanic membrane perforation to avoid ototoxicity.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813481565","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T01:17:21Z","timestamp":1363137441000},"page":"1023-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Topical Oxiconazole and Boric Acid in Alcohol Solutions to Rat Inner Ears"],"prefix":"10.1002","volume":"148","author":[{"given":"S\u00fcleyman","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Cukurova University School of Medicine Department of Otolaryngology\u2013Head and Neck Surgery Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclk\u00fc","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Cukurova University School of Medicine Department of 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