{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:25:36Z","timestamp":1790504736583,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to evaluate clinical application of autologous fat transplantation in the posterior pharynx to treat velopharyngeal incompetence and cleft palate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series with chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Cleft Lip and Palate Center of Plastic Surgery Hospital, an academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>We studied 11 patients (age, 5\u201026 years) with a cleft palate and velopharyngeal insufficiency who underwent autologous fat injection. Patients were followed for 9 to 40\u00a0months. Pronunciation evaluation, visual appearance of the palatopharyngeal area, nasopharyngeal fibroscopy (NPF), palatopharyngeal lateral radiography, and magnetic resonance imaging (MRI) were undertaken before and after the operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Speech intelligibility was markedly increased in all patients. Pronunciation was good to excellent compared with the preoperative level (\n                      <jats:italic>P<\/jats:italic>\n                      =. 001). Mean velopharyngeal insufficiency rate was significantly reduced from 26.05% to 6.96% (\n                      <jats:italic>P<\/jats:italic>\n                      =. 028) by NPF and from 26.42% to 7.11% (\n                      <jats:italic>P<\/jats:italic>\n                      =. 017) by MRI (axial plane). Magnetic resonance imaging indicated significantly reduced mean minimum velopharyngeal distance, from 10.39 to 3.65\u00a0mm (\n                      <jats:italic>P<\/jats:italic>\n                      =. 012) in the sagittal plane, and markedly increased thickness of transplanted fat in the posterior pharyngeal wall (sagittal, 5.43\u00a0mm; axial, 4.74\u00a0mm). There were few complications (sleep apnea, nasopharyngeal regurgitation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autologous fat transplantation in the posterior pharyngeal wall was a good method for treating velopharyngeal incompetence. The safety profile was good in our sample, and we got a consistent result in the follow\u2010up period. In addition, it also could be combined with routine surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599813490893","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T01:29:17Z","timestamp":1369358957000},"page":"284-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Autologous Fat Injection Combined with Palatoplasty and Pharyngoplasty for Velopharyngeal Insufficiency and Cleft Palate: Preliminary Experience"],"prefix":"10.1002","volume":"149","author":[{"given":"Yimei","family":"Cao","sequence":"first","affiliation":[{"name":"The 1st Department of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical School Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"The 1st Department of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical School Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbei","family":"Yin","sequence":"additional","affiliation":[{"name":"The 1st Department of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical School Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"The 1st Department of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical School Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32409-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182564910"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337664"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199907000-00008"},{"key":"e_1_2_9_6_1","first-page":"199","article-title":"About a subcutaneous prosthesis","volume":"21","author":"Gersuny R","year":"1900","journal-title":"Zschr Heilk"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242579"},{"key":"e_1_2_9_8_1","first-page":"72","article-title":"Silicone implants for velopharyngea incompetence: a progress report","volume":"16","author":"Blocksma R","year":"1964","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_9_1","first-page":"47","article-title":"A long term study on treating velopharyngeal insufficiency by Teflon injection","volume":"19","author":"Furlow LT","year":"1982","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1288\/00005537-199003000-00011","article-title":"The use of injectable collagen to correct velopharyngeal insufficiency","volume":"100","author":"Remacle M","year":"1990","journal-title":"Laryngoscope"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.3.268"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181c1fec6"},{"key":"e_1_2_9_13_1","first-page":"153","article-title":"Velar motility, velopharyngeal closure, and speech proficiency in cartilage pharyngoplasty: an eight year study","volume":"5","author":"Hess DA","year":"1968","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(50)80020-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100079500"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811411655"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31824db85b"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.08.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000213"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00015"},{"key":"e_1_2_9_21_1","volume-title":"Sequence Therapy of Cleft Lip and Palate","author":"Wang G","year":"1995"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)31069-5"},{"key":"e_1_2_9_23_1","first-page":"277","volume-title":"Cleft Lip and Palate Repair","author":"Song R"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780190070007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-161"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008210"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1157-7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199003000-00007"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32758-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01578349"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31207"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000097293.56504.00"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.09.033"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-004-0005-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000248110.59452.49"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274731"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1999.3308"},{"key":"e_1_2_9_38_1","first-page":"418","article-title":"MR imaging of fat\u2010containing tumours: the distinction between lipoma and liposarcoma","volume":"51","author":"Jaovisidha S","year":"2010","journal-title":"Singapore Med J"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813490893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599813490893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813490893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:29:52Z","timestamp":1760959792000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599813490893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1177\/0194599813490893"],"URL":"https:\/\/doi.org\/10.1177\/0194599813490893","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]},"assertion":[{"value":"2012-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}