{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:08:08Z","timestamp":1764238088900,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the feasibility of positron emission tomography combined with computed tomography (PET\u2010CT)\u2013guided <jats:sup>125<\/jats:sup>I seed implantation in the treatment of patients with refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 26 patients (18\u00a0men, 8 women; mean age, 51.3 \u00b1 10.8 years; totaling 53 lesions with an average diameter of 2.86 \u00b1 1.61\u00a0cm) were treated by PET\u2010CT\u2013guided <jats:sup>125<\/jats:sup>I seed implantation. All of the patients received a PET\u2010CT scan 2\u00a0months after the treatment. Follow\u2010up was conducted for ~2 to 43\u00a0months (median, 28.2\u00a0months) to observe the local control rate, overall survival rate, and clinical complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The local control rates of refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy after 3, 6, 12, 24, and 36\u00a0months were 90.6% (48\/53), 79.3% (42\/53), 71.7% (38\/53), 62.3% (33\/53), and 56.6% (30\/53), respectively. The overall 1\u2010, 2\u2010, and 3\u2010year survival rates were 87.2%, 71.3%, and 56.5%, respectively, with a median survival time of 28.2\u00a0months. Of all patients, 19.2% (5\/26) died of local recurrence and 15.4% (4\/26) died of metastases. One patient died of hypertensive cerebral hemorrhage, and another patient died from cachexia and infection. The long\u2010term complications included hyperpigmentation at operative sites (n = 5), insensible feeling on the lateral cheek (n = 2), dryness of the oral cavity (n = 1), and headache (n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PET\u2010CT\u2013guided <jats:sup>125<\/jats:sup>I seed implantation is an acceptable and feasible method for treating refractory nasopharyngeal carcinoma with minimal damage and few complications.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813491221","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T02:15:26Z","timestamp":1369793726000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Refractory Nasopharyngeal Carcinoma: Positron Emission Tomography Combined with Computed Tomography\u2013Guided <sup>125<\/sup>I Seed Implantation Therapy after Repeated Traditional Radiochemotherapy"],"prefix":"10.1002","volume":"149","author":[{"given":"Fujun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging &amp; Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou P.R. 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