{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:35:14Z","timestamp":1791272114583,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine whether auditory cortex (AC) organization changed following eighth cranial nerve surgery in adults with vestibular\u2010cochlear nerve pathologies. We examined whether hearing thresholds before and after surgery correlated with increased ipsilateral activation of AC from the intact ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>During magnetic resonance imaging sessions before and 3 and 6\u00a0months after surgery, subjects listened with the intact ear to noise\u2010like random spectrogram sounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Departments of Radiology and Otolaryngology of Washington University School of Medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Three patients with acoustic neuromas received Gamma Knife radiosurgery (GK); 1 patient with Meniere's disease and 5 with acoustic neuromas had surgical resections (SR); 2 of the latter also had GK. Hearing thresholds in each ear were for pure tone stimuli from 250 to 8000\u00a0Hz before and after surgery (3 and 6\u00a0months). At the same intervals, we imaged blood oxygen level\u2013dependent responses to auditory stimulation of the intact ear using an interrupted single\u2010event design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hearing thresholds in 2 of 3\u00a0individuals treated with GK did not change. Five of 6\u00a0individuals became unilaterally deaf after SRs. Ipsilateral AC activity was present before surgery in 6 of 9\u00a0individuals with ipsilateral spatial extents greater than contralateral in 3 of 9. Greater contralateral predominance was significant especially in left compared to right ear affected individuals, including those treated by GK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lateralization of auditory\u2010evoked responses in AC did not change significantly after surgery possibly due to preexisting sensory loss before surgery, indicating that less than profound loss may prompt cortical reorganization.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813495179","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:43:53Z","timestamp":1372293833000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hearing Thresholds and fMRI of Auditory Cortex Following Eighth Cranial Nerve Surgery"],"prefix":"10.1002","volume":"149","author":[{"given":"Harold","family":"Burton","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill B.","family":"Firszt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Washington University School of Medicine St. Louis Missouri 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