{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:59:16Z","timestamp":1792421956302,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the prognostic factors of patients with pathologically negative lymph node (pN0) head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>College medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The medical records of 120 patients were reviewed. Primary tumor sites included 46 larynx, 45 oral cavity, 17 oropharynx, and 12 hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recurrence rate was 14% (17\/120) over a mean observation period of 33\u00a0months. Median <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG)\u2013positron emission tomography (PET)\/computed tomography (CT) maximal standardized uptake value (SUV<jats:sub>max<\/jats:sub>; using 8.5 as a cutoff; <jats:italic>P<\/jats:italic> =. 001), positive surgical margins (<jats:italic>P<\/jats:italic> =. 005), and pathologic T stage (<jats:italic>P<\/jats:italic> =. 012) were found to be associated with recurrence. The 5\u2010year disease\u2010specific survival rate (DSSR) in our cohort was 86%. Patients with an SUV<jats:sub>max<\/jats:sub> value higher than 8.5 and positive surgical margins had significantly decreased 5\u2010year DSSR based on Kaplan\u2010Meier survival curves. Multivariate Cox regression analysis confirmed the significant association between median SUV<jats:sub>max<\/jats:sub> (using 8.5 as a cutoff; hazard ratio [HR], 6.13; 95% confidence interval [CI], 1.79\u201020.93; <jats:italic>P<\/jats:italic> =. 004) and margin involvement (HR, 4.98; 95% CI, 1.42\u201017.47; <jats:italic>P<\/jats:italic> =. 012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A median <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT SUV<jats:sub>max<\/jats:sub> cutoff values of 8.5 or greater and positive surgical margins were associated with adverse outcomes in patients with pN0 head and neck cancer.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813500630","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T01:34:30Z","timestamp":1375839270000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Standardized Uptake Value and Resection Margin Involvement Predict Outcomes in pN0 Head and Neck Cancer"],"prefix":"10.1002","volume":"149","author":[{"given":"Young\u2010Hoon","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie\u2010Ryung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of 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