{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:34:42Z","timestamp":1787765682680,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the treatment outcomes and prognostic factors of injection laryngoplasty (IL) using cross\u2010linked porcine collagen (PC) and hyaluronic acid (HA) in unilateral vocal fold paralysis (UVFP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This study reviewed 60 consecutive patients with UVFP who underwent IL with PC (n = 33) or HA (n = 27). Objective evaluations included maximal phonation time (MPT) and 10\u2010item voice handicap index (VHI\u201010). Kaplan\u2010Meier method was applied to evaluate the subjective treatment outcomes according to the patients\u2019 self\u2010assessment of symptom recurrence via chart review for the follow\u2010up period of 15\u00a0months. Log\u2010rank tests were applied to evaluate the association between clinical factors and subjective treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Objective outcome measurements revealed significantly improved MPT and VHI\u201010 at 1, 3, and 6\u00a0months posttreatment, with nonsignificant differences between the PC and HA groups. Subjective treatment outcomes also revealed a nonsignificant difference between the 2\u00a0groups. The median symptom\u2010free durations were 10.9 and 14.4\u00a0months for the PC and HA groups, respectively. Subsequent analyses failed to identify prognostic significance of sex, time to treatment, etiology, side, injection approaches, and the presence of aspiration. No significant adverse effects occurred during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated comparable subjective and objective improvements following IL using PC or HA in patients with UVFP. No significant prognostic factor of IL was discovered in the present research. Porcine collagen and HA as medium duration materials might play a role in the future of IL.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813508082","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:46:31Z","timestamp":1381884391000},"page":"900-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Treatment Outcomes of Injection Laryngoplasty Using Cross\u2010Linked Porcine Collagen and Hyaluronic Acid"],"prefix":"10.1002","volume":"149","author":[{"given":"Ming\u2010Hsun","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital Taipei Taiwan"},{"name":"Oriental Institute of Technology Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital Taipei Taiwan"},{"name":"Oriental Institute of Technology Taipei Taiwan"},{"name":"Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsu\u2010Wen","family":"Chou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Te","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital Taipei Taiwan"},{"name":"Oriental Institute of Technology Taipei Taiwan"},{"name":"Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199809000-00016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2003.12.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3281084e61"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100307"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(99)80033-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.42"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017701"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20126"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.490"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180caa1b1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33355.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811434003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.11.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.04.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21097"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21965"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(03)00179-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500909"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12021"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00027"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7156.468"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1572"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21258"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.07.011"},{"key":"e_1_2_8_26_1","volume-title":"Operative Techniques in Laryngology","author":"Rosen CA","year":"2008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-003-3022-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90071-E"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900605"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3281084e74"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21130"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2006.10.007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181d0ac75"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200105000-00029"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200212000-00016"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2008.05.007"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900405"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2007.05.006"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20629"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-005-0531-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S3118"},{"key":"e_1_2_8_43_1","first-page":"191","volume-title":"Cosmetic Dermatology: Principles and Practice","author":"Baumann L"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1986.96.11.1248"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33364.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23473"},{"key":"e_1_2_8_47_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0146-0005(97)80013-4","volume-title":"Evidence\u2010Based Medicine: How to Practice and Teach EBM","author":"Sacket DL","year":"1997"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813508082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599813508082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813508082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:53:25Z","timestamp":1760954005000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599813508082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1177\/0194599813508082"],"URL":"https:\/\/doi.org\/10.1177\/0194599813508082","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]},"assertion":[{"value":"2013-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}