{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:03:26Z","timestamp":1781964206650,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Single\u2010modality treatment, either with organ preservation surgery (OPS) or definitive radiation (RT), is the treatment of choice for patients with early supraglottic squamous cell carcinoma (SGC). However, studies comparing the effectiveness of these 2 techniques are lacking. This study compares the survival outcomes in early SGC patients treated with OPS versus RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Secondary data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Surveillance, Epidemiology and End Results database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This study included adult patients with early\u2010stage (T1N0, T2N0) SGC undergoing single\u2010modality treatment with either OPS (with or without neck dissection [ND]) or RT between 1988 and 2008. Survival analysis was used to compare the overall survival (OS) and disease\u2010specific survival (DSS) between patients treated with OPS+ND, OPS alone, and RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2631 T1\/T2\u00a0N0 SGC patients were identified, of whom 167 (6%) were treated with OPS+ND, 186 (7%) with OPS only, and 2278 patients (87%) with definitive RT only. In stage I (T1N0) SGC patients, a significantly better 5\u2010year DSS was noted for both OPS+ND (81% vs 68%, hazard ratio [HR] = 0.61, <jats:italic>P =<\/jats:italic>. 03) and OPS only (82% vs 68%, HR = 0.70, <jats:italic>P<\/jats:italic> =. 05) when compared with definitive RT. For stage II (T2N0) patients, only OPS+ND resulted in a significantly better 5\u2010year DSS (86% vs 60%, HR = 0.31, <jats:italic>P<\/jats:italic> &lt;. 001) when compared with patients treated with RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with early SGC who underwent OPS+ND had better OS and DSS than patients undergoing RT alone. OPS+ND may be considered a viable and preferred treatment option in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813512783","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:18:19Z","timestamp":1384906699000},"page":"237-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Survival Differences between Organ Preservation Surgery and Definitive Radiotherapy in Early Supraglottic Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"150","author":[{"given":"Hassan","family":"Arshad","sequence":"first","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayvel","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cohan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dildeep","family":"Ambujakshan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor R.","family":"Rigual","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Wesley L.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"I. 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