{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:13:54Z","timestamp":1783952034142,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Preclinical data show that exogenous administration of recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) to human oral carcinoma cell lines increases pathogenicity using a nude mouse model. The objectives of this study are to (1) describe the characteristics of baseline protein expression of BMP\u20102\u00a0in head and neck squamous cell carcinomas (HNSCC) and (2) determine if BMP\u20102 expression level correlates with worse oncologic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis of previously harvested patient samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>In total, 149 patients with oral cavity, oropharynx, larynx, and hypopharynx HNSCC treated between January 1, 1997, and December 31, 2004.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A tissue microarray of HNSCC was assembled and immunohistochemistry for BMP\u20102 performed. Staining was quantified using a standardized scoring system. Specimens were dichotomized into high or low expression level. Statistical analyses using log\u2010rank, Wilcoxon, and Fisher exact test were performed for associations between BMP\u20102 protein level and clinicopathologic features and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMP\u20102 expression at any level was noted in 146 of 149 (98%) of samples. Tumors with high BMP\u20102 expression had higher rates of local failure compared with low\u2010expressing tumors (17.3% vs 6.3%; <jats:italic>P<\/jats:italic> =. 04). There was no significant association for BMP\u20102 expression level with tumor location, T stage, N stage, overall survival, regional failure, or distant failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Head and neck squamous cell carcinomas with high baseline BMP\u20102 protein level are associated with higher rates of local recurrence. These data have important implications for using rhBMP\u20102\u00a0in tissue engineering reconstructive approaches in the setting of cancer\u2010related defects.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813513003","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:00:07Z","timestamp":1384815607000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["BMP\u20102 Expression Correlates with Local Failure in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"150","author":[{"given":"Jordan P.","family":"Sand","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Kokorina","sequence":"additional","affiliation":[{"name":"Department of 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