{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:41:30Z","timestamp":1761007290639,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To determine the safety of using a commercially available suspension of polymyxin B, neomycin, and hydrocortisone (PNH) in tympanoplasty surgery. (2) To apply evidence\u2010based medicine to tympanoplasty surgery when considering potential ototoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary otology practice, single surgeon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Approval for this study was obtained from the St. Dominic\u2013Jackson Memorial Hospital Institutional Review Board. Data were gathered on 272 consecutive type 1, underlay tympanoplasties for which both pre\u2010 and postoperative audiometric data were available over a 10\u2010year period. In each surgery, gelatin sponge saturated in a commercially available PNH suspension was placed in the middle ear to support the graft. Patients ranged in age from 3 years to 79 years. Preoperative and postoperative bone conduction thresholds were measured at 500, 1000, 2000, 3000, and 4000\u00a0Hz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average change in sensorineural hearing as measured by bone conduction thresholds was negligible, with a slight improvement in all frequencies tested except 4000\u00a0Hz. The changes by frequencies were as follows: 500\u00a0Hz (\u20131.624\u00a0dB), 1000\u00a0Hz (\u20131.399\u00a0dB), 2000\u00a0Hz (\u20130.975\u00a0dB), 3000\u00a0Hz (\u20130.596\u00a0dB), and 4000\u00a0Hz (+0.560\u00a0dB). The 5\u2010frequency average change was \u22120.545\u00a0dB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The commonly used otic solution containing polymyxin B, neomycin, and hydrocortisone demonstrates no ototoxicity in tympanoplasty surgery and is safe to use in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813513007","type":"journal-article","created":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T01:59:07Z","timestamp":1385171947000},"page":"282-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ototoxicity of Polymyxin B, Neomycin, and Hydrocortisone Suspension in Tympanoplasty Surgery"],"prefix":"10.1002","volume":"150","author":[{"suffix":"III","given":"James R.","family":"House","sequence":"first","affiliation":[{"name":"Jackson Ear Clinic Jackson Mississippi USA"},{"name":"University of Mississippi Medical Center Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"House","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.04.003"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"CD008234","article-title":"Intratympanic gentamicin for Meniere's disease or syndrome","author":"Pullens B","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472882"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.06.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215041615083"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.03.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131209100307"},{"key":"e_1_2_8_12_1","first-page":"782","article-title":"Ear ototoxicity: reality or myth?","volume":"18","author":"Pickett BP","year":"1997","journal-title":"Am J Otol"},{"key":"e_1_2_8_13_1","first-page":"474","article-title":"Safety of ototopical antibiotics","volume":"105","author":"Welling DB","year":"1995","journal-title":"Laryngoscope"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812471499"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813513007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599813513007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599813513007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:09:52Z","timestamp":1760962192000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599813513007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1177\/0194599813513007"],"URL":"https:\/\/doi.org\/10.1177\/0194599813513007","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2013,11,22]]},"assertion":[{"value":"2013-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}