{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:59:57Z","timestamp":1775037597060,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To compare the results of the 2 regimens of treatment at 2\u2010year follow\u2010up and (2) to evaluate the need and the efficacy of retreatment after the recurrence of vertigo attacks in a longer period of follow\u2010up (using the Kaplan\u2010Meier method of analysis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We analyzed 77 patients treated with intratympanic gentamicin (ITG). Thirty\u2010five patients were treated with high\u2010dose (HD) ITG (in total 6\u00a0injections, twice a day, repeated every 3\u00a0days) and 42 with low\u2010dose (LD) ITG (1\u20102\u00a0injections). The results of treatment were evaluated in terms of functional level scale, control of vertigo, and hearing impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 2\u2010year follow\u2010up, a similar percentage of vertigo control was obtained in the 2\u00a0groups; the incidence of hearing loss and posttreatment disequilibrium was significantly higher in patients treated with HD\u2010ITG. The long\u2010term follow\u2010up showed a control of vertigo attacks with a single round of treatment in 71.4% of patients treated with HD\u2010ITG and in 55% of those treated with LD\u2010ITG. With repeated rounds, an effective control of vertigo could be achieved in 88.5% using a HD\u2010ITG protocol and 97.7% using a LD\u2010ITG protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LD\u2010ITG allows obtaining good results in term of vertigo attacks associated with a limited occurrence of side effects. The long\u2010term follow\u2010up showed that LD\u2010ITG needed repeated rounds more frequently than the HD\u2010protocol. HD\u2010ITG ran less risk of needing repeated rounds, but retreatment was ineffective in 40% of the cases requiring surgical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813520398","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T23:25:54Z","timestamp":1391037954000},"page":"847-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Intratympanic Gentamicin for M\u00e9ni\u00e8re's Disease: Short\u2010 and Long\u2010term Follow\u2010up of Two Regimens of Treatment"],"prefix":"10.1002","volume":"150","author":[{"given":"Augusto P.","family":"Casani","sequence":"first","affiliation":[{"name":"Department of Surgery and Medicine Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Cerchiai","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Navari","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Dallan","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Piaggi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Sellari\u2010Franceschini","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"CD008234","article-title":"Intratympanic gentamicin for M\u00e9ni\u00e8re's disease or syndrome","author":"Pullens B","year":"2011","journal-title":"Cochrane Database Syst. 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