{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:07:42Z","timestamp":1783444062160,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Steroid\u2010eluting spacers can improve local drug delivery immediately following endoscopic sinus surgery and reduce the recurrence of inflammation warranting systemic corticosteroids. For chronic rhinosinusitis with nasal polyposis, the need for systemic corticosteroids immediately following endoscopic sinus surgery when using a steroid\u2010eluting spacer has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic rhinology practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Chronic rhinosinusitis patients with nasal polyposis who failed medical therapy and elected endoscopic sinus surgery were enrolled. Patients were randomized into either the treatment arm (postoperative prednisone 30\u00a0mg daily \u00d7 7\u00a0days; n = 18) or placebo arm (postoperative placebo pill daily \u00d7 7\u00a0days; n = 18). Outcomes were evaluated at 1 week, 3 weeks, and 2\u00a0months postoperatively. Primary outcome was endoscopic grading at postoperative month 2 using the Lund\u2013Kennedy system. Secondary outcome included disease\u2010specific quality of life using the Sinonasal Outcome Test (SNOT\u201022) survey. Patient enrolment occurred from January 2012 through February 2013 (NCT01564355).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both arms received significant improvement in endoscopic grading and disease\u2010specific quality of life from baseline compared to 2\u2010month follow\u2010up (<jats:italic>P<\/jats:italic> &lt;. 001). There were no significant differences in mean endoscopic scores between the postoperative prednisone and control groups at 1 week (<jats:italic>P<\/jats:italic> =. 715), 3 weeks (<jats:italic>P<\/jats:italic> =. 883), or 2\u00a0months (<jats:italic>P<\/jats:italic> =. 343). There were no significant differences in SNOT\u201022 scores between groups at all follow\u2010up points (all <jats:italic>P<\/jats:italic> &gt;. 119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Minimizing systemic corticosteroid use in patients with chronic rhinosinusitis with nasal polyposis may avoid adverse events. Results from this study suggest that postoperative systemic corticosteroids immediately following endoscopic sinus surgery may not provide improved outcomes when utilizing a steroid\u2010eluting spacer.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814521373","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T23:17:47Z","timestamp":1391123867000},"page":"689-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Role of Immediate Postoperative Systemic Corticosteroids When Utilizing a Steroid\u2010eluting Spacer Following Sinus Surgery"],"prefix":"10.1002","volume":"150","author":[{"given":"Jon F.","family":"Dautremont","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery University of Calgary Calgary Alberta 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