{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:37Z","timestamp":1761007537340,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of twice\u2010daily proton pump inhibitor (PPI) treatment on the relationship between laryngopharyngeal pH environment and symptoms in patients with laryngopharyngeal reflux (LPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>Retrospective analysis of records from consecutive patients seen at a single clinical site between 2009 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Forty\u2010three records of patients diagnosed with LPR who underwent pre\u2010 and posttreatment pH studies were included. Prior to treatment, all had a Reflux Symptom Index (RSI) &gt; 13 and an abnormal pH study. Patients were treated for \u2265 4 weeks with twice\u2010daily PPIs. Following treatment, patients completed a second RSI and pH study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (67.4%) had symptom normalization; however, most patients (60.5%) did not have pH normalization. For all patients whose symptoms did not normalize, pH scores also did not normalize; 32.6% of patients showed no subjective or objective treatment response. For individuals whose symptoms normalized but whose pH scores did not normalize, there was a significant decrease in upright pH score. For the entire group, pretreatment symptom and upright pH scores were strongly positively correlated. Improvements in symptom and upright pH scores following treatment were moderately positively correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laryngopharyngeal pH failed to normalize for most individuals after PPI treatment; only pH improvement was necessary for symptom normalization. Many patients had no treatment response. Laryngopharyngeal reflux patients may make up a heterogeneous group, and PPI responsivity may help explain conflicting results from previous studies. Posttreatment pH monitoring is recommended in studies investigating the efficacy of PPI therapy for LPR.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814525577","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T01:34:46Z","timestamp":1395279286000},"page":"1010-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Proton Pump Inhibitor Therapy for Laryngopharyngeal Reflux on Posttreatment Symptoms and Hypopharyngeal pH"],"prefix":"10.1002","volume":"150","author":[{"given":"Jonathan","family":"Waxman","sequence":"first","affiliation":[{"name":"College of Medicine University of Illinois at Chicago Chicago Illinois USA"},{"name":"ChicagoENT Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreeya","family":"Yalamanchali","sequence":"additional","affiliation":[{"name":"ChicagoENT Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Shay","family":"Valle","sequence":"additional","affiliation":[{"name":"College of Medicine University of Illinois at Chicago Chicago Illinois USA"},{"name":"ChicagoENT Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pott","sequence":"additional","affiliation":[{"name":"ChicagoENT Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Friedman","sequence":"additional","affiliation":[{"name":"ChicagoENT Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center Chicago Illinois USA"},{"name":"Rush University Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1067\/mhn.2002.125760"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1080\/17549500701862287"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1164\/ajrccm.163.4.2005136"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1177\/000348940111000703"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1007\/s00405-009-1044-2"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"539","article-title":"Driving performance in patients with chronic obstructive pulmonary disease","volume":"59","author":"Orth M","year":"2008","journal-title":"J Physiol Pharmacol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.4104\/pcrj.2009.00020"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.mehy.2009.04.042"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1002\/lary.1991.101.s53.1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1177\/000348940111001203"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1002\/lary.23619"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1001\/archotol.132.9.995"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1097\/01.mlg.0000192173.00498.ba"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/j.otohns.2008.06.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1111\/j.1572-0241.2006.00844.x"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"CD005054","article-title":"Acid reflux treatment for hoarseness","author":"Hopkins C","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.2147\/TCRM.S6862"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1111\/j.1365-2036.2006.03213.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1016\/S0892-1997(02)00097-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/j.jvoice.2007.12.005"},{"issue":"1","key":"e_1_2_8_22_1","first-page":"1","article-title":"Review article: reflux and its consequences\u2014the laryngeal, pulmonary and oesophageal manifestations. 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