{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:15:40Z","timestamp":1781010940516,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess sinonasal outcomes in patients with aspirin exacerbated respiratory disease (AERD) undergoing aspirin desensitization following endoscopic sinus surgery (ESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A retrospective review of sinonasal outcomes was conducted for 30 AERD patients undergoing aspirin desensitization and maintenance therapy following ESS. Sinonasal outcomes were prospectively assessed by the Sinonasal Outcomes Test\u201022 (SNOT\u201022) and endoscopic polyp grading system. Data were collected preoperatively, 1 and 4 weeks postsurgery (before desensitization), and 1, 6, 12, 18, 24, and 30\u00a0months after aspirin desensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight of 30 patients (93.3%) successfully completed aspirin desensitization, whereas 2 of 30 (6.7%) were unable to complete desensitization due to respiratory intolerance. Of the 21 patients who successfully completed a minimum of 24 weeks of follow\u2010up, 20 (95.2%) patients demonstrated sustained endoscopic and symptomatic improvement for a median follow\u2010up period of 33\u00a0months. After surgical treatment but before desensitization, patients experienced significant reductions in SNOT\u201022 and polyp grade scores. In the first 6\u00a0months after aspirin desensitization, patients experienced further significant reductions in SNOT\u201022 scores, whereas polyp grade remained stable. The improvements in symptom endoscopic scores were preserved throughout the follow\u2010up period after desensitization. No patients required additional sinus surgery. One patient had to discontinue aspirin therapy due to gastrointestinal side effects. No other adverse reactions to aspirin were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin desensitization following ESS appears to be a well\u2010tolerated and effective adjunctive therapy for long\u2010term control of nasal polyposis in patients with AERD.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814545750","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T10:06:18Z","timestamp":1407924378000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Long\u2010term Sinonasal Outcomes of Aspirin Desensitization in Aspirin Exacerbated Respiratory Disease"],"prefix":"10.1002","volume":"151","author":[{"given":"Kyu\u2010Sup","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Biomedical Research Institute Pusan National University School of Medicine Pusan National University Hospital 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