{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:04:27Z","timestamp":1792735467770,"version":"4.5.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01RR006192\/RR\/NCRR"],"award-info":[{"award-number":["M01RR006192\/RR\/NCRR"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007710","name":"University of Connecticut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Serum biomarkers detect the earliest events in disease, monitor management, and provide insight into disease pathogenesis. At this time, there are no biomarkers available for otologic disorders. Otolin\u20101 is a scaffolding protein exclusively expressed in otoconia and cells of the vestibule and the cochlea; therefore, it may be a biomarker candidate for assessing the health of the inner ear. As a proof of concept, we used serum samples from controls without otologic history and subjects with a history of benign paroxysmal positional vertigo (BPPV), performed enzyme\u2010linked immunosorbent assay for otolin\u20101, and measured the optical density of the substrate. Otolin\u20101 was detectable and quantifiable in all subjects, indicating that this inner ear protein crosses the blood\u2010labyrinthine barrier. Furthermore, subjects with BPPV had significantly higher levels, with about one\u2010third being above the control range. This promising preliminary result suggests that inner ear\u2013specific proteins have the potential to serve as biomarkers for otologic disease processes.<\/jats:p>","DOI":"10.1177\/0194599814551127","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T03:24:09Z","timestamp":1411442649000},"page":"1038-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Inner Ear Protein as a Biomarker in Circulation?"],"prefix":"10.1002","volume":"151","author":[{"given":"Kourosh","family":"Parham","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of Connecticut Health Center Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sacks","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of Connecticut Health Center Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bixby","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of Connecticut Health Center Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Fall","sequence":"additional","affiliation":[{"name":"Clinical Research Center University of Connecticut Health Center Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012765"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020498"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.07.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24162"},{"key":"e_1_2_7_7_1","first-page":"3","volume-title":"Biological Markers in Epidemiology","author":"Hulka BS","year":"1990"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.182"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814551127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599814551127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814551127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:15:42Z","timestamp":1760951742000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599814551127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1177\/0194599814551127"],"URL":"https:\/\/doi.org\/10.1177\/0194599814551127","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]},"assertion":[{"value":"2014-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}