{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:04:51Z","timestamp":1772165091826,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin\/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical\/systemic steroids, endoscopic sinus surgery, and\/or aspirin desensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2\u00a0groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was conducted in a tertiary otolaryngology clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>Patients with AERD were enrolled in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjective (Sino\u2010nasal Outcome Test\u201022 [SNOT\u201022], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire\u20107 [ACQ\u20107]) and objective outcome instruments (Peri\u2010Operative Sinus Evaluation [POSE] and Lund\u2010Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT\u201022\u00a0p\n                      <jats:sub>LS<\/jats:sub>\n                      = 0.0059, NSSS p\n                      <jats:sub>LS<\/jats:sub>\n                      = 0.0195, LKES p\n                      <jats:sub>LS<\/jats:sub>\n                      = 0.0039, POSE p\n                      <jats:sub>LS<\/jats:sub>\n                      = 0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599814555836","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T23:34:54Z","timestamp":1414193694000},"page":"42-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study"],"prefix":"10.1002","volume":"152","author":[{"given":"Doron D.","family":"Sommer","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery McMaster University Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Hoffbauer","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery McMaster University Hamilton 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