{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:30:53Z","timestamp":1786494653852,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE\u2010123762"],"award-info":[{"award-number":["MFE\u2010123762"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to identify clinical factors that are predictive of depression and quality of life (QOL) among long\u2010term survivors of head and neck squamous cell carcinoma and to develop predictive scores using these factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cohort study<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 209 posttreatment (median follow\u2010up, 38.7\u00a0months) head and neck cancer patients were prospectively evaluated using the Hospital Anxiety Depression Scale (HADS), the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30, and the EORTC Quality of Life Questionnaire Head and Neck 35, and pretreatment patient\u2010related, tumor\u2010related, and treatment\u2010related predictors were identified using chart review. Bivariate (\u03c7<jats:sup>2<\/jats:sup> and <jats:italic>t<\/jats:italic> test) and multivariate (linear regression) analyses were used to construct predictive models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant pretreatment predictors of depression were identified on multivariate analysis as smoking at diagnosis, &gt;14 alcoholic drinks per week, T3 or T4 status, and &gt;3\u00a0medications (<jats:italic>P<\/jats:italic> &lt;. 001). Two or more of these factors yielded an 82.3% sensitivity in detecting significant depressive symptoms (defined as a HADS cutoff score of 5). Significant predictors of fatigue, global health\/QOL, social contact, speech, pain, swallowing, and xerostomia were also identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pretreatment predictors of long\u2010term depression and QOL have been defined using multivariate models, and an easily applicable predictive score of long\u2010term depression is proposed. Potential eventual clinical applications include prophylactic intervention in at\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814557772","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:52:56Z","timestamp":1415926376000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Predicting Depression and Quality of Life among Long\u2010term Head and Neck Cancer Survivors"],"prefix":"10.1002","volume":"152","author":[{"given":"Sami P.","family":"Moubayed","sequence":"first","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"},{"name":"Division of Surgical Research Department of Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Sampalis","sequence":"additional","affiliation":[{"name":"Division of Surgical Research Department of Surgery McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareck","family":"Ayad","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Guertin","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bissada","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olguta E.","family":"Gologan","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Souli\u00e8res","sequence":"additional","affiliation":[{"name":"Medical Oncology Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Filion","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc Felix","family":"Nguyen\u2010Tan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery Service Universit\u00e9 de Montr\u00e9al Hospital Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812437332"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.2853"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.734"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1188\/09.ONF.E107-E125"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1545"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.3.1505473"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8941"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl385"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_9_11_1","volume-title":"Applied Multiple Regression\/Correlation Analysis for the Behavioral Sciences","author":"Cohen J","year":"2003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1129"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.234"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0880"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.03.024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.91"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-005-0011-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.18"},{"key":"e_1_2_9_20_1","article-title":"The nature and extent of body image concerns among surgically treated patients with head and neck cancer [published online June 27, 2011]","author":"Fingeret MC","journal-title":"Psychooncology"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2005.07.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199901)21:1<1::AID-HED1>3.0.CO;2-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017788"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.853"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20491"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900812"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.106"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-10-200205210-00013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2007.174144"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-20"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-21"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200001000-00018"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510027547"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20370"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21702"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200012)22:8<799::AID-HED9>3.0.CO;2-E"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.4.401"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200500055418"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70141-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199601\/02)18:1<1::AID-HED1>3.0.CO;2-7"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199707)19:4<243::AID-HED1>3.0.CO;2-0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199810000-00027"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.528"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.12.1345-a"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70148-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0480-7"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814557772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599814557772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814557772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:54:19Z","timestamp":1760950459000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599814557772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1177\/0194599814557772"],"URL":"https:\/\/doi.org\/10.1177\/0194599814557772","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,13]]},"assertion":[{"value":"2014-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}