{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:00:41Z","timestamp":1793109641348,"version":"4.5.0"},"reference-count":364,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1\u00a0in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually. Not surprisingly, myriad diagnostic tests and treatments are used in managing this disorder, yet there is considerable variation in their use. This clinical practice guideline was undertaken to optimize the care of patients with AR by addressing quality improvement opportunities through an evaluation of the available evidence and an assessment of the harm\u2010benefit balance of various diagnostic and management options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The primary purpose of this guideline is to address quality improvement opportunities for all clinicians, in any setting, who are likely to manage patients with AR as well as to optimize patient care, promote effective diagnosis and therapy, and reduce harmful or unnecessary variations in care. The guideline is intended to be applicable for both pediatric and adult patients with AR. Children under the age of 2 years were excluded from the clinical practice guideline because rhinitis in this population may be different than in older patients and is not informed by the same evidence base. The guideline is intended to focus on a limited number of quality improvement opportunities deemed most important by the working group and is not intended to be a comprehensive reference for diagnosing and managing AR. The recommendations outlined in the guideline are not intended to represent the standard of care for patient management, nor are the recommendations intended to limit treatment or care provided to individual patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Action Statements<\/jats:title><jats:p>The development group made a <jats:italic>strong recommendation<\/jats:italic> that clinicians recommend intranasal steroids for patients with a clinical diagnosis of AR whose symptoms affect their quality of life. The development group also made a <jats:italic>strong recommendation<\/jats:italic> that clinicians recommend oral second\u2010generation\/less sedating antihistamines for patients with AR and primary complaints of sneezing and itching. The panel made the following <jats:italic>recommendations<\/jats:italic>: (1) Clinicians should make the clinical diagnosis of AR when patients present with a history and physical examination consistent with an allergic cause and 1 or more of the following symptoms: nasal congestion, runny nose, itchy nose, or sneezing. Findings of AR consistent with an allergic cause include, but are not limited to, clear rhinorrhea, nasal congestion, pale discoloration of the nasal mucosa, and red and watery eyes. (2) Clinicians should perform and interpret, or refer to a clinician who can perform and interpret, specific IgE (skin or blood) allergy testing for patients with a clinical diagnosis of AR who do not respond to empiric treatment, or when the diagnosis is uncertain, or when knowledge of the specific causative allergen is needed to target therapy. (3) Clinicians should assess patients with a clinical diagnosis of AR for, and document in the medical record, the presence of associated conditions such as asthma, atopic dermatitis, sleep\u2010disordered breathing, conjunctivitis, rhinosinusitis, and otitis media. (4) Clinicians should offer, or refer to a clinician who can offer, immunotherapy (sublingual or subcutaneous) for patients with AR who have inadequate response to symptoms with pharmacologic therapy with or without environmental controls.<\/jats:p><jats:p>The panel <jats:italic>recommended against<\/jats:italic> (1) clinicians routinely performing sinonasal imaging in patients presenting with symptoms consistent with a diagnosis of AR and (2) clinicians offering oral leukotriene receptor antagonists as primary therapy for patients with AR.<\/jats:p><jats:p>The panel group made the following options: (1) Clinicians may advise avoidance of known allergens or may advise environmental controls (ie, removal of pets; the use of air filtration systems, bed covers, and acaricides [chemical agents formulated to kill dust mites]) in patients with AR who have identified allergens that correlate with clinical symptoms. (2) Clinicians may offer intranasal antihistamines for patients with seasonal, perennial, or episodic AR. (3) Clinicians may offer combination pharmacologic therapy in patients with AR who have inadequate response to pharmacologic monotherapy. (4) Clinicians may offer, or refer to a surgeon who can offer, inferior turbinate reduction in patients with AR with nasal airway obstruction and enlarged inferior turbinates who have failed medical management. (5) Clinicians may offer acupuncture, or refer to a clinician who can offer acupuncture, for patients with AR who are interested in nonpharmacologic therapy. The development group provided <jats:italic>no recommendation<\/jats:italic> regarding the use of herbal therapy for patients with AR.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814561600","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T12:04:01Z","timestamp":1422878641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":433,"title":["Clinical Practice Guideline"],"prefix":"10.1002","volume":"152","author":[{"given":"Michael D.","family":"Seidman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Henry Ford West Bloomfield Hospital West Bloomfield Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Department of Surgery Otolaryngology\u2013Head and Neck Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine Department of Otolaryngology\u2013Head and Neck Surgery Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth R.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad M.","family":"Baroody","sequence":"additional","affiliation":[{"name":"University of Chicago Medical Center Department of Otolaryngology Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bonner","sequence":"additional","affiliation":[{"name":"Birmingham VA Medical Center Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Otolaryngology, Private Practice Muscatine Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Dykewicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St Louis University School of Medicine St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse M.","family":"Hackell","sequence":"additional","affiliation":[{"name":"Pomona Pediatrics Pomona New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Ishman","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene J.","family":"Krouse","sequence":"additional","affiliation":[{"name":"Wayne State University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James (Whit) W.","family":"Mims","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Health Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folashade S.","family":"Omole","sequence":"additional","affiliation":[{"name":"Morehouse School of Medicine East Point Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Acupuncture and Oriental Medicine (AAAOM) Annandale Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana V.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Florida Atlantic University, Boca Raton Florida and Nova Southeastern University Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Consumers United for Evidence\u2010based Healthcare Fredericton New Brunswick Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Warren","sequence":"additional","affiliation":[{"name":"Consumers United for Evidence\u2010based Healthcare Fredericton New Brunswick Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan N.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Louisiana State University School of Medicine New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine C.","family":"Nnacheta","sequence":"additional","affiliation":[{"name":"Department of Research and Quality American Academy of Otolaryngology\u2014Head and Neck Surgery Foundation Alexandria Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.2.65"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20003"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.3.148"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.10.014"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3329"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812468849"},{"key":"e_1_2_14_10_1","first-page":"1","volume":"8","author":"National ambulatory medical care utilization estimates for 2006","year":"2008","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1106"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22034"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62022-4"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125003053"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2934"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112552"},{"key":"e_1_2_14_18_1","first-page":"121","article-title":"Seasonal allergic rhinitis and antihistamine effects on children\u2019s learning","volume":"71","author":"Vuurman EF","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap2008.29.3072"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2012.2.2.93"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21123"},{"key":"e_1_2_14_22_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.otohns.2009.04.015","article-title":"Clinical practice guideline development manual: a quality\u2010driven approach for translating evidence into action","volume":"140","author":"Rosenfeld RM","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000172"},{"key":"e_1_2_14_24_1","doi-asserted-by":"crossref","unstructured":"ShiffmanRN ShekelleP OverhageJ et al.Standardized reporting of clinical practice guidelines: a proposal from the Conference on Guideline Standardization.Ann Intern Med.2003;139(6):493\u2013498.","DOI":"10.7326\/0003-4819-139-6-200309160-00013"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-5-23"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1260"},{"key":"e_1_2_14_27_1","unstructured":"Oxford Centre for Evidence\u2010Based Medicine.OCEBM Levels of Evidence Working Group. The Oxford 2011 levels of evidence.http:\/\/www.cebm.net\/index.aspx?o=5653.Accessed April 24 2014."},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.612"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.061181"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1109283"},{"key":"e_1_2_14_31_1","volume-title":"Management of allergic and non\u2010allergic rhinitis","author":"Long A","year":"2002"},{"key":"e_1_2_14_32_1","unstructured":"Allergic Rhinitis Guideline Team.UMHS clinical guideline on allergic rhinitis.University of Michigan Health System.October 2013.http:\/\/www.med.umich.edu\/1info\/fhp\/practiceguides\/allergic\/allergic.pdf.Accessed April 24 2014."},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39365.617905.BE"},{"issue":"67","key":"e_1_2_14_34_1","first-page":"1","article-title":"Management of allergic rhinitis in the working\u2010age population","author":"McCrory DC","year":"2003","journal-title":"Evid Rep Technol Assess (Summ)"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03450.x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.8.1018"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.1.2.115.62907"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079904X13266"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60305-5"},{"issue":"3","key":"e_1_2_14_40_1","first-page":"593","article-title":"Introduction to in vivo allergy testing","volume":"109","author":"Anon JB","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.185"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61034-4"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70146-8"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01398-6"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2382"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90088-0"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.12.014"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62195-3"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62037-6"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3382"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.582"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03937.x"},{"key":"e_1_2_14_54_1","unstructured":"Consumerhealthchoices.org.Allergy tests: when you need them\u2014and when you don\u2019t.2012.http:\/\/consumerhealthchoices.org\/wp\u2010content\/uploads\/2012\/07\/ChoosingWiselyAllergyTestsAAAAI\u2010ER.pdf.Accessed July 17 2014."},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131209100309"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083953"},{"issue":"3","key":"e_1_2_14_57_1","first-page":"169","article-title":"Eosinophilia in nasal secretions compared to skin prick test and nasal challenge test in the diagnosis of nasal allergy","volume":"30","author":"Romero JN","year":"1992","journal-title":"Rhinology"},{"key":"e_1_2_14_58_1","unstructured":"American College of Radiology.ACR position statement on recent studies regarding CT scans and increased cancer risk.2009.http:\/\/www.acr.org\/About\u2010Us\/Media\u2010Center\/Position\u2010Statements\/Position\u2010Statements\u2010Folder\/ACR\u2010Statement\u2010on\u2010Recent\u2010Studies\u2010Regarding\u2010CT\u2010Scans\u2010and\u2010Increased\u2010Cancer\u2010Risk.Accessed March 4 2014."},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.3.2343107"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.032"},{"key":"e_1_2_14_63_1","unstructured":"American College of Radiology (ACR) appropriateness criteria.Sinonasal disease.2012.http:\/\/www.acr.org\/~\/media\/ACR\/Documents\/AppCriteria\/Diagnostic\/SinonasalDisease.pdf.Accessed March 4 2014."},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812463848"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.02.015"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb01714.x"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334148"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03925.x"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70227-7"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05406-X"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043214"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-013-0412-6"},{"issue":"7","key":"e_1_2_14_73_1","first-page":"CD001563","article-title":"House dust mite avoidance measures for perennial allergic rhinitis","author":"Sheikh A","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_14_74_1","first-page":"CD001563","article-title":"House dust mite avoidance measures for perennial allergic rhinitis","author":"Sheikh A","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"489","key":"e_1_2_14_75_1","first-page":"318","article-title":"House dust mite avoidance measures for perennial allergic rhinitis: a systematic review of efficacy","volume":"53","author":"Sheikh A","year":"2003","journal-title":"Br J Gen Pract"},{"issue":"1","key":"e_1_2_14_76_1","first-page":"CD001563","article-title":"House dust mite avoidance measures for perennial allergic rhinitis","author":"Sheikh A","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02752.x"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023171"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02024.x"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1999.40.3.238"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90050-E"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.03.006"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00934.x"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900500446823"},{"key":"e_1_2_14_85_1","first-page":"S138","article-title":"Rhinitis is ubiquitous in allergic asthmatics","volume":"99","author":"Kapsali T","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.06.004"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328357cc32"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.041"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70074-9"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.064"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.10.002"},{"issue":"2","key":"e_1_2_14_92_1","first-page":"103","article-title":"The effects of a new generation of H(1) antihistamines (cetirizine and loratadine) on histamine release and the bronchial response to histamine in atopic patients","volume":"5","author":"Chyrek\u2010Borowska S","year":"1995","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90322-7"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90079-H"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21511"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001905779"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90177-7"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12124"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.58.9"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.9909087"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90021-8"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0343"},{"issue":"8","key":"e_1_2_14_103_1","first-page":"CD001186","article-title":"Injection allergen immunotherapy for asthma","author":"Abramson MJ","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01068.x"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f1d67e"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.08.020"},{"issue":"4","key":"e_1_2_14_107_1","first-page":"E17","article-title":"Impaired mucociliary clearance in allergic rhinitis patients is related to a predisposition to rhinosinusitis","volume":"88","author":"Vlastos I","year":"2009","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04038.x"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.004"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01130.x"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835ff132"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3280f3c09f"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.12.001"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61084-8"},{"issue":"4","key":"e_1_2_14_115_1","first-page":"268","article-title":"The effect of intranasal steroid budesonide on the congestion related sleep disturbance and daytime somnolence in patients with perennial allergic rhinitis","volume":"26","author":"Gurevich F","year":"2005","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"e_1_2_14_116_1","first-page":"53","article-title":"The effect of topical nasal fluticasone on objective sleep testing and the symptoms of rhinitis, sleep and daytime somnolence in perennial allergic rhinitis","volume":"24","author":"Craig T","year":"2003","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62434-9"},{"issue":"5","key":"e_1_2_14_118_1","first-page":"CD003002","article-title":"Drug therapy for obstructive sleep apnoea in adults","author":"Mason M","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90198-4"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706113162403"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00928.x"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90068-X"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70053-3"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113188"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80017-X"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.02102.x"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2896"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03654.x"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01808.x"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115567"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.623"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70171-X"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3509"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00093.x"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.04.020"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104550"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61955-2"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-2918(95)80088-3"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.02.022"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70326-4"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80101-0"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90039-I"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105225"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62057-1"},{"key":"e_1_2_14_145_1","first-page":"331","article-title":"The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis","volume":"24","author":"DeWester J","year":"2003","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02543.x"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.015"},{"issue":"4","key":"e_1_2_14_148_1","first-page":"CD003570","article-title":"Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis","author":"Taramarcaz P","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7173.1624"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62085-6"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.020"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.10.030"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap2007.28.3033"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3058"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60854-X"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3593"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3571"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3490"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60171-8"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.10.023"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.2165\/0044011-200929020-00002"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01521.x"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.12.025"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60373-0"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00096.x"},{"key":"e_1_2_14_166_1","first-page":"17","article-title":"Local safety of intranasal triamcinolone acetonide: clinical and histological aspects of nasal mucosa in the long term treatment of perennial allergic rhinitis","volume":"39","author":"Klosek JM","year":"2001","journal-title":"Rhinology"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.2.193"},{"key":"e_1_2_14_168_1","first-page":"81","article-title":"Long term efficacy and safety of beclomethasone dipropionate aerosol in perennial rhinitis","volume":"50","author":"Knight A","year":"1983","journal-title":"Ann Allergy"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1988.tb02867.x"},{"key":"e_1_2_14_170_1","first-page":"648","article-title":"Assessment by nasal biopsy of longterm use of mometosone furoate aqueous nasal spray in the treatment of perennial rhinitis","volume":"118","author":"Minshall E","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00649.x"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3675"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90317-9"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01040.x"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-2918(95)80040-9"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70085-5"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70223-3"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70379-3"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.96"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1089\/pai.2007.002"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60624-2"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60476-0"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60340-7"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00775.x"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00627.x"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00299.x"},{"key":"e_1_2_14_187_1","volume-title":"Norvir [package insert].","year":"2008"},{"key":"e_1_2_14_188_1","volume-title":"Kaletra [package insert].","year":"2005"},{"key":"e_1_2_14_189_1","volume-title":"Prezista [package insert].","year":"2010"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74627-6"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139807701012"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00043005"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540330044033"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb00807.x"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb18030.x"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.08.017"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63615-0"},{"key":"e_1_2_14_198_1","first-page":"407","article-title":"No growth suppression in children treated with the maximum recommended dose of fluticasone propionate aqueous nasal spray for one year","volume":"23","author":"Allen DB","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.e22"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60322-5"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.09.004"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90418-1"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00351.x"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2002.01509.x"},{"issue":"1","key":"e_1_2_14_205_1","first-page":"25","article-title":"Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis","volume":"37","author":"Ciprandi G","year":"2005","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02544.x"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.005"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600104"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.e116"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70172-1"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.0117.x"},{"issue":"4","key":"e_1_2_14_212_1","first-page":"275","article-title":"Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5\u201012 hours postdose, in the environmental exposure unit","volume":"26","author":"Day JH","year":"2005","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0486"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.08.012"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1550"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63062-1"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2008.29.3166"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)90009-2"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb00741.x"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63057-8"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.01.006"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.02.003"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62518-5"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3594"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61573-6"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121703"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.3.223"},{"issue":"8","key":"e_1_2_14_228_1","first-page":"1123","article-title":"First\u2010line treatment of seasonal (ragweed) rhinoconjunctivitis: a randomized management trial comparing a nasal steroid spray and a nonsedating antihistamine","volume":"156","author":"Juniper EF","year":"1997","journal-title":"CMAJ"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb02586.x"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.01.016"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.630389"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X80305"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.08.010"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61468-8"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62179-5"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90148-1"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63420-5"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.08.005"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60408-5"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60355-9"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3626"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63128-6"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3296"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.06.008"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61174-X"},{"key":"e_1_2_14_246_1","first-page":"368","article-title":"A clinical review of montelukast in the treatment of seasonal allergic rhinitis","volume":"38","author":"Gonyeau MJ","year":"2003","journal-title":"Formulary"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01276.x"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61339-7"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767060-00005"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.164"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070218"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61409-3"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900902847727"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079904X3348"},{"key":"e_1_2_14_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21018"},{"key":"e_1_2_14_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.011"},{"key":"e_1_2_14_257_1","unstructured":"Merck Sharp & Dohme Corp. Singulair product information.2012.uspi\u20100476\u2010mf\u20101308r030.www.merck.com\/product\/usa\/pi_circulars\/s\/singulair\/singulair_pi.pdf.Accessed January 22 2014."},{"key":"e_1_2_14_258_1","unstructured":"Food and Drug Administration.Follow\u2010up to the March 27 2008 communication about the ongoing safety review of montelukast (Singulair).2009.http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/DrugSafetyInformationforHeathcareProfessionals\/ucm079523.htm.Accessed July 17 2014."},{"key":"e_1_2_14_259_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3293"},{"key":"e_1_2_14_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60452-8"},{"key":"e_1_2_14_261_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03258482"},{"issue":"7","key":"e_1_2_14_262_1","first-page":"CD006989","article-title":"Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children","author":"Nasser M","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"e_1_2_14_263_1","first-page":"325","article-title":"Efficacy of once\u2010daily desloratadine\/pseudoephedrine for relief of nasal congestion","volume":"23","author":"Schenkel E","year":"2002","journal-title":"Allergy Asthma Proc"},{"issue":"2","key":"e_1_2_14_264_1","first-page":"67","article-title":"Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis","volume":"35","author":"Grosclaude M","year":"1997","journal-title":"Rhinology"},{"key":"e_1_2_14_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70001-3"},{"key":"e_1_2_14_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.10.023"},{"key":"e_1_2_14_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60986-6"},{"key":"e_1_2_14_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70120-X"},{"issue":"5","key":"e_1_2_14_269_1","first-page":"391","article-title":"Efficacy and safety of desloratadine\/pseudoephedrine tablet, 2.5\/120\u00a0mg two times a day, versus individual components in the treatment of patients with seasonal allergic rhinitis","volume":"26","author":"Chervinsky P","year":"2005","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_14_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63460-6"},{"key":"e_1_2_14_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63423-0"},{"key":"e_1_2_14_272_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-199807000-00007"},{"key":"e_1_2_14_273_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1686"},{"key":"e_1_2_14_274_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770900903104540"},{"key":"e_1_2_14_275_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3881"},{"key":"e_1_2_14_276_1","first-page":"89","article-title":"Efficacy of montelukast and loratadine as treatment for allergic rhinitis in children","volume":"26","author":"Watanasomsiri A","year":"2008","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_14_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61891-1"},{"key":"e_1_2_14_278_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2001.00964.x"},{"key":"e_1_2_14_279_1","first-page":"63","article-title":"Concomitant levocetirizine and montelukast in the treatment of seasonal allergic rhinitis: influence on clinical symptoms","volume":"16","author":"Lombardo G","year":"2006","journal-title":"Italian Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_14_280_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106040"},{"key":"e_1_2_14_281_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20941"},{"key":"e_1_2_14_282_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00416.x"},{"key":"e_1_2_14_283_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3514"},{"key":"e_1_2_14_284_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01877.x"},{"key":"e_1_2_14_285_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124467"},{"key":"e_1_2_14_286_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.5.557"},{"key":"e_1_2_14_287_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2010.32.9.1533686"},{"key":"e_1_2_14_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.05.017"},{"key":"e_1_2_14_289_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP47071"},{"key":"e_1_2_14_290_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3587"},{"key":"e_1_2_14_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.077"},{"issue":"2","key":"e_1_2_14_292_1","first-page":"109","article-title":"A clinical comparison of budesonide nasal aerosol, terfenadine and a combined therapy of budesonide and oxymetazoline in adult patients with perennial rhinitis","volume":"8","author":"Lau SK","year":"1990","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_14_293_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3864"},{"key":"e_1_2_14_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.037"},{"key":"e_1_2_14_295_1","first-page":"85","article-title":"Efficacy of fluticasone and oxymetazoline as the treatment for allergic rhinitis","volume":"6","author":"Matreja PS","year":"2012","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_14_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.12.014"},{"key":"e_1_2_14_297_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2049"},{"key":"e_1_2_14_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.034"},{"key":"e_1_2_14_299_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24295"},{"issue":"1","key":"e_1_2_14_300_1","first-page":"CD001936","article-title":"Allergen injection immunotherapy for seasonal allergic rhinitis","author":"Calderon MA","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.049"},{"issue":"2","key":"e_1_2_14_302_1","first-page":"CD002893","article-title":"Sublingual immunotherapy for allergic rhinitis","author":"Wilson DR","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_303_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02583.x"},{"key":"e_1_2_14_304_1","volume-title":"Allergen\u2010specific immunotherapy for the treatment of allergic rhinoconjunctivitis and\/or asthma: comparative effectiveness review. No. 111. (Prepared by the Johns Hopkins University Evidence\u2010based Practice Center under Contract No. 290\u20102007\u201010061\u2010I.)","author":"Lin SY","year":"2013"},{"key":"e_1_2_14_305_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03835.x"},{"key":"e_1_2_14_306_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121317"},{"key":"e_1_2_14_307_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.012"},{"key":"e_1_2_14_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60211-6"},{"key":"e_1_2_14_309_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70388-X"},{"key":"e_1_2_14_310_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01451.x"},{"key":"e_1_2_14_311_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.030"},{"key":"e_1_2_14_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.040"},{"key":"e_1_2_14_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.02.006"},{"key":"e_1_2_14_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70055-0"},{"key":"e_1_2_14_315_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02761.x"},{"key":"e_1_2_14_316_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01998.x"},{"key":"e_1_2_14_317_1","unstructured":"Food and Drug Administration (FDA) Briefing Document (Oralair Grastek and Ragwitek package insert).Biologic License Application (BLA) for Sweet Vernal Orchard Perennial Rye Timothy and Kentucky Blue Grass Mixed Pollens Allergen Extract Tablet for Sublingual Use(11 December 2013). APAC Briefing document:1\u201316.http:\/\/www.fda.gov\/downloads\/advisorycommittees\/committeesmeetingmaterials\/bloodvaccinesandotherbiologics\/allergenicproductsadvisorycommittee\/ucm377852.pdf.Accessed June 10 2014."},{"key":"e_1_2_14_318_1","unstructured":"Food and Drug Administration.Oralair package insert.2014.http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/Allergenics\/UCM391580.pdf.Accessed June 10 2014."},{"key":"e_1_2_14_319_1","unstructured":"Food and Drug Administration.Grastek package insert.2014.http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/Allergenics\/UCM393184.pdf.Accessed June 10 2014."},{"key":"e_1_2_14_320_1","unstructured":"Food and Drug Administration.Ragwitek package insert.2014.http:\/\/www.fda.gov\/downloads\/biologicsbloodvaccines\/allergenics\/ucm393600.pdf.Accessed June 10 2014."},{"key":"e_1_2_14_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.013"},{"key":"e_1_2_14_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.04.005"},{"key":"e_1_2_14_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.08.012"},{"key":"e_1_2_14_324_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02861.x"},{"key":"e_1_2_14_325_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta17270"},{"key":"e_1_2_14_326_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21061"},{"key":"e_1_2_14_327_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200806"},{"key":"e_1_2_14_328_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000205140.44181.45"},{"key":"e_1_2_14_329_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1462-1"},{"key":"e_1_2_14_330_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00645.x"},{"key":"e_1_2_14_331_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200101000-00025"},{"key":"e_1_2_14_332_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00016"},{"key":"e_1_2_14_333_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23469.x"},{"key":"e_1_2_14_334_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1308"},{"key":"e_1_2_14_335_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0744"},{"key":"e_1_2_14_336_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60330-4"},{"key":"e_1_2_14_337_1","first-page":"450","article-title":"Protective effect of acupuncture on allergen provoked rhinitis","volume":"148","author":"Wolkenstein E","year":"1998","journal-title":"Wien Med Wochenschr"},{"key":"e_1_2_14_338_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.14.1.6"},{"key":"e_1_2_14_339_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0200020X"},{"key":"e_1_2_14_340_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04001813"},{"key":"e_1_2_14_341_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01275.x"},{"key":"e_1_2_14_342_1","first-page":"104","article-title":"Study on cytokines IL\u20102, IL\u20106, IL\u201010\u00a0in patients of chronic allergic rhinitis treated with acupuncture","volume":"22","author":"Petti FB","year":"2002","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_14_343_1","first-page":"229","article-title":"Effect of acupuncture on nasal obstruction in patients with persistent allergic rhinitis: a randomized controlled trial","volume":"22","author":"Park YC","year":"2005","journal-title":"J Kor Acu Mox"},{"key":"e_1_2_14_344_1","first-page":"557","article-title":"Therapeutic effect of acupuncture on allergic rhinitis and its effects on immunologic function [in Chinese]","volume":"26","author":"Rao YQ","year":"2006","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_14_345_1","first-page":"136","article-title":"Effects of electroacupuncture on allergic plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients","volume":"32","author":"Li YM","year":"2007","journal-title":"Acupunct Res"},{"key":"e_1_2_14_346_1","first-page":"535","article-title":"Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial","volume":"101","author":"Brinkhaus B","year":"2008","journal-title":"Ann Intern Med"},{"key":"e_1_2_14_347_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00002"},{"key":"e_1_2_14_348_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12053"},{"key":"e_1_2_14_349_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-2299(03)00124-9"},{"key":"e_1_2_14_350_1","doi-asserted-by":"publisher","DOI":"10.1054\/npep.1999.0759"},{"key":"e_1_2_14_351_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2000.6.519"},{"key":"e_1_2_14_352_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00317-8"},{"key":"e_1_2_14_353_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90251-N"},{"key":"e_1_2_14_354_1","first-page":"934","article-title":"Certain progress of clinical research on Chinese integrative medicine","volume":"112","author":"Chen K","year":"1999","journal-title":"Chin Med J"},{"key":"e_1_2_14_355_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.02.010"},{"key":"e_1_2_14_356_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000225156.29780.36"},{"key":"e_1_2_14_357_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365170"},{"key":"e_1_2_14_358_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00540.x"},{"key":"e_1_2_14_359_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62386-1"},{"key":"e_1_2_14_360_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.6.1303"},{"key":"e_1_2_14_361_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237245"},{"key":"e_1_2_14_362_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.029"},{"key":"e_1_2_14_363_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250533"},{"key":"e_1_2_14_364_1","volume-title":"Complementary and Integrative Therapies for ENT Disorders, An Issue of Otolaryngologic Clinics","author":"Maddalozzo J","year":"2013"},{"issue":"1","key":"e_1_2_14_365_1","first-page":"34","article-title":"Allergies and asthma: alternatives in treatment","volume":"15","author":"Seidman MD","year":"1999","journal-title":"Hearing Health"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814561600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599814561600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814561600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:53:47Z","timestamp":1760961227000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599814561600"}},"subtitle":["Allergic Rhinitis"],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":364,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1177\/0194599814561600"],"URL":"https:\/\/doi.org\/10.1177\/0194599814561600","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"2014-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}