{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:33:31Z","timestamp":1778290411581,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was designed to evaluate 4D computerized tomography (CT) as a means of localizing abnormal parathyroid glands in primary hyperparathyroidism (HPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with expertized image review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 38 patients were recruited for study, all of whom had undergone focused parathyroidectomy for single\u2010lesion primary HPT between June 2011 and September 2013. In each patient, 3 imaging procedures were performed: cervical ultrasonography (US), <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi SPECT\/CT (SeS), and 4D CT. Collective imaging data were blindly reviewed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4D CT outperformed US and SeS in terms of sensitivity (<jats:italic>P<\/jats:italic> =. 27), specificity (<jats:italic>P<\/jats:italic> =. 01), positive predictive value (PPV) (<jats:italic>P<\/jats:italic> &lt;. 01), negative predictive value (NPV) (<jats:italic>P<\/jats:italic> =. 19), and accuracy (<jats:italic>P<\/jats:italic> &lt;. 01). In 7.9% (3\/38) of patients, 4D CT provided specific anatomic information that was unaffordable by US and SeS. Localization by 4D CT correlated with tissue parathyroid hormone level (<jats:italic>P<\/jats:italic> =. 02), maximum diameter (<jats:italic>P<\/jats:italic> =. 01), and volume (<jats:italic>P<\/jats:italic> &lt;. 01) of abnormal parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>4D CT proved helpful in localizing target parathyroid glands of primary HPT that were missed by traditional imaging.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814562195","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T13:40:38Z","timestamp":1418910038000},"page":"438-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Comparison of 4D CT, Ultrasonography, and <sup>99m<\/sup>Tc Sestamibi SPECT\/CT in Localizing Single\u2010Gland Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"152","author":[{"given":"Yong Joon","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Surgery Seoul National University Bundang Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Kook","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi Jeong","family":"Cheon","sequence":"additional","affiliation":[{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Nuclear Medicine Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo\u2010Kyu","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.10.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1106636"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3168"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr225"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318208fed9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2012.04.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.12.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2021-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-012-0142-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.049"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2805"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2012.01.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.06.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp032200"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-881-4_17"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.09.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-1004-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1870-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1507-0"},{"key":"e_1_2_9_24_1","first-page":"157","article-title":"4D CT\u2010A diagnostic tool to localize an occult parathyroid adenoma in a patient with primary hyperparathyroidism","volume":"95","author":"Beland MD","year":"2012","journal-title":"Med Health R I"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1365-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38905.634132.AE"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1348885"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2512-2"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814562195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599814562195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814562195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:18:39Z","timestamp":1760966319000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599814562195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0194599814562195"],"URL":"https:\/\/doi.org\/10.1177\/0194599814562195","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]},"assertion":[{"value":"2014-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}