{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:08:10Z","timestamp":1784693290274,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A systematic review and meta\u2010analysis of the evidence on balloon Eustachian tuboplasty (BET) as a treatment modality for Eustachian tube dysfunction (ETD). We followed the PRISMA guideline and registered with PROSPERO No. CRD42014009461.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>We searched 12 databases including PubMed and Embase from January 1, 2010, to April 7, 2014, for studies of BET. Endpoints: change in symptoms, middle ear pathology, eardrum status, Eustachian tube function tests, hearing, adverse events, complications, and health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Study quality was assessed using the modified Delphi technique quality appraisal tool for case series studies. Risk of bias was assessed using the Cochrane Collaboration\u2019s tool for assessing risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine case series studies with 443 patients (642 tubes) were included. Population size n = 4 (7 tubes) to n = 210 (320 tubes). All studies were of poor quality and featured a high risk of bias. We found reduction of patient symptoms in ETD questionnaire (<jats:italic>P<\/jats:italic> &lt;. 001), postoperative normalization of the tympanic membrane, conversion of type B or type C into type A tympanograms, reduced mucosal inflammation, increased number of positive Valsalva test and Swallowing tests, improvement in Eustachian tube score, reduction in Sino\u2010Nasal Outcome Test (SNOT)\u201022 score (<jats:italic>P<\/jats:italic> =. 001), and increased quality of life (<jats:italic>P<\/jats:italic> =. 001). No serious adverse events were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The evidence of BET is poor and biased. No firm conclusions can be made to identify patients who will benefit from the procedure or to accurately predict surgical results. Randomized controlled trials or case\u2010control trials are needed.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599814567105","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:42:19Z","timestamp":1421800939000},"page":"383-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Balloon Eustachian Tuboplasty"],"prefix":"10.1002","volume":"152","author":[{"given":"Thomas Skov","family":"Randrup","sequence":"first","affiliation":[{"name":"Department of ENT, Head and Neck Surgery Aarhus University Hospital \u00c5rhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of ENT, Head and Neck Surgery Aarhus University Hospital \u00c5rhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.08.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1992.tb01004.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.56"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21453"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12220"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-013-2691-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20950"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23181"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.11.008"},{"key":"e_1_2_10_12_1","unstructured":"PRISMA.Home page.http:\/\/www.prisma\u2010statement.org\/.Accessed April 30 2014."},{"key":"e_1_2_10_13_1","unstructured":"PROSPERO\u2014international prospective register of systematic reviews. Home page.http:\/\/www.crd.york.ac.uk\/PROSPERO\/prospero.asp.Accessed April 30 2014."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23223"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500601"},{"key":"e_1_2_10_17_1","unstructured":"Development of a quality appraisal tool for case series studies using a modified delphi technique.http:\/\/www.ihe.ca\/documents\/Case%20series%20studies%20using%20a%20modified%20Delphi%20technique.pdf.Accessed April 30 2014."},{"key":"e_1_2_10_18_1","unstructured":"Cochrane handbook for systematic reviews of interventions.http:\/\/www.cochrane.org\/handbook.Accessed April 30 2014."},{"key":"e_1_2_10_19_1","unstructured":"OluwasanmiA.Balloon eustachian tuboplast (BET).http:\/\/www.controlled\u2010trials.com.Accessed April 30 2014."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358254"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31826a50c3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2243-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811399866"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-012-2573-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814529538"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-013-2711-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181e8cc6d"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-013-2712-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000214"},{"key":"e_1_2_10_31_1","first-page":"1324","article-title":"Otologic manifestations of petrous carotid aneurysms","volume":"26","author":"Moonis G","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215113003563"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.3559"},{"key":"e_1_2_10_35_1","volume-title":"Fibro\u2010Cartilaginous Eustachian Tube\u2010Middle Ear Cleft","author":"Ars B","year":"2003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-009-1908-1"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814567105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599814567105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599814567105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:19:00Z","timestamp":1760966340000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599814567105"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0194599814567105"],"URL":"https:\/\/doi.org\/10.1177\/0194599814567105","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,20]]},"assertion":[{"value":"2014-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}