{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:22:09Z","timestamp":1793247729362,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the effects of zinc and steroid in the treatment of traumatic anosmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective, randomized study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients with a clear history of loss of smell after head injury and whose thresholds were \u22121\u00a0measured by the phenyl ethyl alcohol threshold test were included in this study from January 2010 to May 2013. They were randomly divided into 4\u00a0groups. Patients in group 1 were treated with zinc gluconate for a month and high\u2010dose prednisolone with tapering for 2 weeks. Those in group 2 took only zinc gluconate, and those in group 3 took only prednisolone. Patients in group 4 did not take any medicine. All patients were followed up by phenyl ethyl alcohol threshold testing, and magnetic resonance imaging was performed to measure the volume of olfactory bulbs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients in group 1, 35\u00a0in group 2, 34\u00a0in group 3, and 37\u00a0in group 4 completed the study. The recovery of olfactory function was observed in 11 patients (28.2%) in group 1, in 9 (25.7%) in group 2, in 4 (11.8%) in group 3, and in 1 (2.7%) in group 4. The recovery rates of olfactory function of groups 1 and 2 were significantly higher than the recovery rate of group 4. The volume of olfactory bulbs was not significantly different between those with and without improved olfactory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that zinc gluconate has a promising effect in treating traumatic anosmia.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815571272","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T04:49:27Z","timestamp":1424926167000},"page":"954-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Medical Treatment of Traumatic Anosmia"],"prefix":"10.1002","volume":"152","author":[{"given":"Rong\u2010San","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wen","family":"Twu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Li","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming Medical University Taipei 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