{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:48:52Z","timestamp":1778064532644,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of unilateral nasal obstruction (by nasal polyps of different histopathology) on olfactory bulb volume using MRI technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary university hospitals, Departments of Otolaryngology and Radiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Eleven patients with a few months of complete unilateral nasal obstruction of different pathological etiologies were selected. MRI assessment of olfactory bulb volume was performed using planimetric manual contouring. The contralateral olfactory bulb was used as a comparative control for the same patient. Eleven healthy controls constituted the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean olfactory bulb volume \u00b1SD of obstructed side = 14.3 \u00b1 3.7\u00a0mm<jats:sup>3<\/jats:sup>, mean olfactory bulb volume \u00b1SD of nonobstructed side = 43.49 \u00b1 10.7\u00a0mm<jats:sup>3<\/jats:sup>. The difference between the 2 sides was significant (<jats:italic>P<\/jats:italic> =. 003). The difference in olfactory bulb volume between normal subjects and nonobstructed nasal side was statistically nonsignificant (<jats:italic>t<\/jats:italic> =. 9118, <jats:italic>P<\/jats:italic> =. 3727), while the difference between normal subjects\u2019 olfactory bulb volume and obstructed nasal side olfactory bulb volume in our patients was extremely statistically significant (<jats:italic>t<\/jats:italic> = 9.7320, <jats:italic>P<\/jats:italic> &lt;. 0001). A strong negative correlation was found between duration of obstruction and olfactory bulb volume (<jats:italic>R<\/jats:italic> = \u22120.9761).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that unilateral nasal obstruction may be associated with a lateralized ipsilateral difference of olfactory bulb volume.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815573196","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T21:52:30Z","timestamp":1425937950000},"page":"959-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ipsilateral Reduced Olfactory Bulb Volume in Patients with Unilateral Nasal Obstruction"],"prefix":"10.1002","volume":"152","author":[{"given":"Sherif M.","family":"Askar","sequence":"first","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail S.","family":"Elnashar","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad W.","family":"El\u2010Anwar","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem S.","family":"Amer","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A.","family":"El Shawadfy","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh M.","family":"Hosny","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed F.","family":"Bazeed","sequence":"additional","affiliation":[{"name":"Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman F.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona A.","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2832-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.6.621"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200504040-00011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3768"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.136"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-011-9129-0"},{"key":"e_1_2_8_10_1","first-page":"156","article-title":"Olfactory testing in clinical settings\u2014is there additional benefit from unilateral 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