{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:23:46Z","timestamp":1789590226920,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the applicability of magnetic resonance imaging (MRI) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, randomized, controlled, double\u2010blind study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>One single tertiary care institution in a large, cosmopolitan city.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients (n = 42 ears) with clinical, audiometric, and tomographic diagnosis of otosclerosis were enrolled. If computed tomography (CT) demonstrated active lesions, these patients underwent MRI to detect otospongiotic foci, seen as areas of gadolinium enhancement. Patients were divided into 3\u00a0groups and received treatment with placebo, sodium alendronate, or sodium fluoride for 6\u00a0months. After this period, clinical and audiometric evaluations and a second MRI were performed. Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective (visual) and objective (using specific eFilm Workstation software) manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Otospongiosis was most predominantly identified in the region anterior to the oval window, and this site was reliable for comparing pre\u2010 and posttreatment scans. The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions, more relevant in the alendronate group. These findings were statistically significant for both subjective and objective MRI evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis. The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815574698","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T10:24:18Z","timestamp":1426847058000},"page":"1119-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Magnetic Resonance Imaging in the Evaluation of Clinical Treatment of Otospongiosis"],"prefix":"10.1002","volume":"152","author":[{"given":"Andy","family":"de Oliveira Vicente","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Imaging Diagnosis Universidade Federal de S\u00e3o Paulo\u2013Escola Paulista de Medicina S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujana S.","family":"Chandrasekhar","sequence":"additional","affiliation":[{"name":"New York Otology New York Head and Neck Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio K.","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Imaging Diagnosis Universidade Federal de S\u00e3o Paulo\u2013Escola Paulista de Medicina S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo Laercio M.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Imaging Diagnosis Universidade Federal de S\u00e3o Paulo\u2013Escola Paulista de Medicina S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia A.","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Imaging Diagnosis Universidade Federal de S\u00e3o Paulo\u2013Escola Paulista de Medicina S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma O.","family":"Penido","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Imaging Diagnosis Universidade Federal de S\u00e3o Paulo\u2013Escola Paulista de Medicina S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"206","article-title":"Enzymology of otospongiosis and NaF therapy","volume":"1","author":"Causse JR","year":"1980","journal-title":"Am J Otol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300043361"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486709128767"},{"key":"e_1_2_8_5_1","first-page":"482","article-title":"Sodium fluoride therapy","volume":"14","author":"Causse JR","year":"1993","journal-title":"Am J Otol"},{"key":"e_1_2_8_6_1","unstructured":"WebMD.Florical side effects.http:\/\/www.webmd.com\/drugs\/2\/drug\u20107917\/florical\u2010oral\/details\/list\u2010sideeffects.Accessed October 30 2014."},{"key":"e_1_2_8_7_1","first-page":"47","article-title":"CT densitometry in otosclerosis","volume":"37","author":"Valvassori GE","year":"1987","journal-title":"Adv Otorhinoaryngol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30815-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200207000-00006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510401014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810701214"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)85008-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.75.894.750502"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067565"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942012000200012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.49"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400201"},{"key":"e_1_2_8_19_1","first-page":"20","article-title":"Otospongiosis and sodium fluoride: a clinical double\u2010blind, placebo\u2010controlled study on sodium fluoride treatment in otospongiosis","volume":"10","author":"Bretlau P","year":"1989","journal-title":"Am J Otol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900312"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050445"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00036"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815574698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599815574698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815574698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:47:21Z","timestamp":1760964441000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599815574698"}},"subtitle":["A Pilot Study"],"short-title":[],"issued":{"date-parts":[[2015,3,19]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/0194599815574698"],"URL":"https:\/\/doi.org\/10.1177\/0194599815574698","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,19]]},"assertion":[{"value":"2014-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}