{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:22:36Z","timestamp":1792840956951,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prosthetics serve as an option for nasoseptal perforation treatment in patients who have active systemic disease, are poor surgical candidates, or wish to avoid surgery. Through systematic review of the literature on prosthetics for nasoseptal perforation treatment, the objective of the present study is to critically appraise previous studies, evaluate the success rate for nasoseptal prosthetics, provide evidence\u2010based guidelines for nasoseptal prosthetic use, and identify areas for further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Cochrane Controlled Trials Register, EMBASE, PubMed, and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Data sources were queried for relevant articles published from 1965 to 2013. Articles were selected for inclusion if they presented primary data for human nasoseptal perforation treatment utilizing prosthetic materials. Each included article\u2019s level of evidence and risk of bias were identified and grades of recommendation were assigned. A quantitative meta\u2010analysis was performed on articles with low risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search yielded 4756 abstracts for review, with 23\u00a0included case series and 5 case reports; 706 total cases of prosthetic nasoseptal perforation treatment were identified. All articles provided level 4 evidence, with an overall conclusion grade of C for improvement in nasoseptal perforation symptoms, prosthetic in situ rate, and complication rate. Meta\u2010analysis of 6 low\u2010risk\u2010of\u2010bias studies with 297 patients demonstrated an overall success rate of 65%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The literature provides level 4 evidence for the efficacy and safety of prosthetics for nasoseptal perforation treatment with favorable success rates and few reports of complications\u2014only 1 fungal infection and 9 unspecified infections\u2014in 706 cases.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815577084","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T23:27:28Z","timestamp":1428535648000},"page":"803-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Prosthetics for Nasoseptal Perforations"],"prefix":"10.1002","volume":"152","author":[{"given":"Robert J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Sherris","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University at Buffalo The State University of New York Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.03.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472881"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.11.1236"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6987.1122"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.07.006"},{"key":"e_1_2_10_7_1","volume-title":"Methods Guide for Effectiveness and Comparative Effectiveness Reviews","author":"Viswanathan M","year":"2008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-849X.2012.00911.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12073"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817c4296"},{"key":"e_1_2_10_11_1","first-page":"35","article-title":"Insertion of nasal septal button in the treatment of septal perforation: a case report","volume":"9","author":"Belic B","year":"2008","journal-title":"Ser J Exp Clin Res"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-998070"},{"key":"e_1_2_10_13_1","first-page":"33","article-title":"Closure of a septal perforation by means of an obturator","volume":"13","author":"Van Dishoeck EA","year":"1975","journal-title":"Rhinology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000273725"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221502761698720"},{"key":"e_1_2_10_16_1","first-page":"694","article-title":"Experience with individual obturators to treat nasal septum perforation","volume":"91","author":"Al Kadah B","year":"2012","journal-title":"Laryngorhinootologie"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0690-0"},{"key":"e_1_2_10_18_1","first-page":"324","article-title":"Silicone button in nasal septal perforation: long term observations","volume":"46","author":"Dosen LK","year":"2008","journal-title":"Rhinology"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-941635"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100089179"},{"key":"e_1_2_10_21_1","first-page":"216","article-title":"Management of nasal septal perforation using silicone nasal septal button","volume":"26","author":"Mullace M","year":"2006","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"1","key":"e_1_2_10_22_1","first-page":"9","article-title":"Septal perforations: are septal buttons better? 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