{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:05:39Z","timestamp":1787724339892,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety, tolerability, and voice outcomes of office\u2010based photoangiolytic laser treatment of Reinke\u2019s edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We performed a retrospective analysis of patients undergoing office\u2010based laser treatment of endoscopy\u2010proven Reinke\u2019s edema. Safety and tolerability were evaluated by reviewing complications. Voice outcomes were analyzed by comparing pre\u2010 and postprocedural acoustic, aerodynamic, and Voice Handicap Index measurements. Complete data sets were not available for all subjects; sample size for each parameter is reported with the corresponding result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients met inclusion criteria. There were no minor or major complications. Five procedures were truncated due to patient intolerance. Phonatory frequency range increased (n = 12, <jats:italic>P<\/jats:italic> =. 003), while percent jitter decreased (n = 12, <jats:italic>P<\/jats:italic> =. 004). Phonation threshold pressure decreased after treatment (n = 4, <jats:italic>P<\/jats:italic> =. 049). Voice Handicap Index also decreased (n = 14, <jats:italic>P<\/jats:italic> &lt;. 001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study represents the largest series of patients undergoing office\u2010based photoangiolytic laser treatment specifically for Reinke\u2019s edema. Our data suggest that this is a safe and effective modality to treat dysphonia associated with Reinke\u2019s edema, although patient intolerance of the procedure may represent a barrier.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815577104","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T00:53:00Z","timestamp":1427590380000},"page":"1075-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Office\u2010Based Photoangiolytic Laser Treatment of Reinke\u2019s Edema"],"prefix":"10.1002","volume":"152","author":[{"given":"Ian J.","family":"Koszewski","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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