{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:10:01Z","timestamp":1760965801926,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The feasibility of parathyroid preservation during thyroidectomy has not been well documented for cases in which the thyroid gland extends into the mediastinum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In this retrospective cohort study, 70 consecutive patients who had substernal thyroid glands treated with a transcervical thyroidectomy between 1993 and 2013 were compared with 286 thyroidectomies that did not entail substernal extension within that same time period. All localized parathyroid glands were confirmed histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 160 possible parathyroid glands in the substernal cases, 119 (74%) were histologically confirmed intraoperatively (67 superior and 52\u00a0inferior). In nonsubsternal cases, 725 (89%) were histologically confirmed (372 superior and 353\u00a0inferior). There was a statistically significant difference between the substernal and nonsubsternal cases in the total number of glands found (<jats:italic>P<\/jats:italic> &lt;. 0001) and the number of superior and inferior glands that were identified (<jats:italic>P<\/jats:italic> =. 009 and &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even when the thyroid gland extends into the mediastinum, it is often possible, although with reduced efficiency, to identify and preserve the parathyroid glands.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815578105","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T22:12:17Z","timestamp":1428358337000},"page":"1024-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Parathyroid Localization and Preservation during Transcervical Resection of Substernal Thyroid Glands"],"prefix":"10.1002","volume":"152","author":[{"given":"Thomas E.","family":"Heineman","sequence":"first","affiliation":[{"name":"Weill Cornell Medical College New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajoy","family":"Kadkade","sequence":"additional","affiliation":[{"name":"Hofstra North Shore\u2013Long Island Jewish School of Medicine Department of Otolaryngology &amp; Communicative Disorders North Shore\u2013Long Island Jewish Medical Center Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Kutler","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College\/New York Presbyterian Department of Otolaryngology\u2013Head and Neck Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College\/New York Presbyterian Department of Otolaryngology\u2013Head and Neck Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I.","family":"Kuhel","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College\/New York Presbyterian Department of Otolaryngology\u2013Head and Neck Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700450304"},{"first-page":"179","volume-title":"Operative Techniques in Otolaryngology\u2013Head and Neck Surgery","author":"Fritts L","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(85)80086-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480206800306"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9466-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-007-3659-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199803000-00009"},{"first-page":"179","volume-title":"Operative Techniques in Otolaryngology and Head and Neck Surgery","author":"Cohen JP","key":"e_1_2_7_9_1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199908)21:5<442::AID-HED10>3.0.CO;2-Z"},{"key":"e_1_2_7_11_1","first-page":"969","article-title":"Rationale for the operative management of substernal goiters","volume":"94","author":"Allo MD","year":"1983","journal-title":"Surgery"},{"key":"e_1_2_7_12_1","first-page":"826","article-title":"Surgical management of substernal goiter: analysis of 237 patients","volume":"61","author":"Torre G","year":"1995","journal-title":"Am J Surg"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(98)90106-5"},{"key":"e_1_2_7_14_1","first-page":"327","article-title":"Preservation of the parathyroid glands in total thyroidectomy","volume":"165","author":"Schwartz AE","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.61"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815578105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599815578105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815578105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:47:36Z","timestamp":1760964456000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599815578105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/0194599815578105"],"URL":"https:\/\/doi.org\/10.1177\/0194599815578105","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2015,4,6]]},"assertion":[{"value":"2014-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}