{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:53:15Z","timestamp":1767675195709,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids. Pain control is still a big problem after tonsillectomy surgery. We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post\u2010tonsillectomy pain management. This is the first\u2010time use of montelukast in post\u2010tonsillectomy pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Double\u2010blind, controlled\u2010randomized study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>University teaching and research hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist class I\u2010II, scheduled for elective tonsillectomy were enrolled in this clinical trial study. The patients were randomized into 2\u00a0groups: the montelukast group (group M, n = 30) and control group (group C, n = 30). Group M recieved an oral montelukast tablet and group C recieved placebo at 2400pm on the morning before surgery. Post\u2010tonsillectomy pain was evaluated with the Wong\u2010Baker FACES Scale during the 24 hours after surgery. Patients\u2019 intraoperative hemodynamic parameters and intraoperative and postoperative complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant differences between group C and group M for Wong\u2010Baker FACES pain rating scale scores (<jats:italic>P<\/jats:italic> &lt;. 05). In the 24 hours after surgery, the total number of patients using rescue analgesics was higher in group C than in group M, and the difference was statistically significant (<jats:italic>P<\/jats:italic> &lt;. 001). There was no significant difference in demographic parameters (<jats:italic>P<\/jats:italic> &gt;. 05). There were no significant differences in postoperative nausea and vomiting, otalgia, trismus, fever, or halitosis between the groups (<jats:italic>P<\/jats:italic> &gt;. 05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preemptive montelukast can be used safely to reduce the serious pain caused by tonsillectomy in children.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815580976","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T22:52:22Z","timestamp":1429224742000},"page":"269-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Does Montelukast Have an Effect on Post\u2010tonsillectomy Pain Control in Children? A Randomized Trial Study"],"prefix":"10.1002","volume":"153","author":[{"given":"Ilker","family":"Ince","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation Ataturk University School of Medicine Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Yoruk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Ataturk University School of Medicine Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ahiskalioglu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Ataturk University School of Medicine Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Ataturk University School of Medicine Erzurum 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