{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:40:17Z","timestamp":1760971217334,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000114"],"award-info":[{"award-number":["UL1TR000114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence and severity of dysphonia in patients with cystic fibrosis sinusitis. We hypothesized that patients with CF sinusitis, compared with 2 control groups, would have higher self\u2010reported prevalence of dysphonia and greater severity of dysphonia, according to patient\u2010reported outcome measures as well as auditory\u2010perceptual evaluation by expert listeners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional comparative pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic tertiary care clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Participants and Methods<\/jats:title><jats:p>Analysis included 37 study participants: 17 patients with CF sinusitis, 10 healthy individuals, and 10 patients with non\u2010CF sinusitis. All participants completed the 10\u2010item Voice Handicap Index (VHI\u201010) questionnaire and provided voice samples. On all samples, 6 blinded speech\u2010language pathologists independently performed auditory\u2010perceptual evaluation, using Consensus Auditory\u2010Perceptual Evaluation of Voice. To assess severity of sinonasal symptoms, we used the 20\u2010item Sinonasal Outcome Test (SNOT\u201020). Standard parametric and nonparametric statistical analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The differences between the 3\u00a0groups in prevalence of abnormal VHI\u201010 scores were not statistically significant. SNOT\u201020 scores were similar in the 2 sinusitis patient groups. VHI\u201010 scores were highest in patients with CF sinusitis, intermediate in patients with non\u2010CF sinusitis, and lowest in healthy individuals (<jats:italic>P<\/jats:italic> =. 005). Auditory\u2010perceptual evaluation demonstrated greater overall severity of dysphonia in patients with CF sinusitis compared with the 2 control groups (<jats:italic>P<\/jats:italic> =. 0005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cystic fibrosis sinusitis appeared to be associated with worse vocal function as measured by patient self\u2010report as well as auditory\u2010perceptual evaluation of voice compared with patients with non\u2010CF sinusitis and healthy controls. Further investigation in this area is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815581832","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T22:41:30Z","timestamp":1430174490000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Severity of Dysphonia in Patients with Cystic Fibrosis"],"prefix":"10.1002","volume":"153","author":[{"given":"John","family":"Willis","sequence":"first","affiliation":[{"name":"Lions Voice Clinic Department of Otolaryngology Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre D.","family":"Michael","sequence":"additional","affiliation":[{"name":"Lions Voice Clinic Department of Otolaryngology Head and Neck Surgery University of Minnesota Minneapolis Minnesota 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