{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:18Z","timestamp":1787018718926,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to clarify the outcomes of craniofacial resection for locally advanced maxillary sinus carcinoma classified as T4 and to present methods for managing cases involving the skull base.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series with chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary university hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>We performed anterolateral craniofacial resection in en bloc fashion for locally advanced maxillary sinus carcinoma at stage T4. Participants comprised 40 patients with T4\u00a0maxillary sinus carcinoma treated between 1992 and 2011. Surgical outcomes were analyzed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty patients with stage T4a (n = 26) or stage T4b (n = 14) were included in this study. Five\u2010year overall and disease\u2010free survival rates for the 40 patients with T4\u00a0maxillary sinus carcinoma were 62.7% and 52.6%, respectively. Cavernous sinus involvement correlated significantly with worse prognosis (\n                      <jats:italic>P<\/jats:italic>\n                      =. 012). In 35 cases without cavernous sinus involvement, previous treatment (\n                      <jats:italic>P<\/jats:italic>\n                      =. 017) and positive margins (\n                      <jats:italic>P<\/jats:italic>\n                      =. 019) correlated significantly with worse prognosis, and 5\u2010year overall and disease\u2010free survival rates were 72.4% and 55.3%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study only included cases of locally advanced maxillary sinus carcinoma classified as T4. Considering the advanced stage, our study suggests relatively favorable outcomes and the importance of managing the cavernous sinus in en bloc resections of malignant skull base tumors. Craniofacial resection in en bloc fashion achieved good survival rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599815586770","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T23:36:58Z","timestamp":1433461018000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Craniofacial Resection for T4\u00a0Maxillary Sinus Carcinoma"],"prefix":"10.1002","volume":"153","author":[{"given":"Naoki","family":"Nishio","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya 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