{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:05:25Z","timestamp":1771333525402,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Sentinel lymph node biopsy (SLNB) is standard practice for intermediate\u2010thickness head and neck melanoma (HNM) but remains controversial for melanomas more than 4\u00a0mm in thickness. The objectives of this study were to evaluate (1) the diagnostic accuracy and (2) the prognostic value of SLNB in patients with thick HNM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Large cancer center between June 2000 and December 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>77 patients undergoing SLNB for T4 HNM without in\u2010transit, regional, or distant metastatic disease at presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Univariate and multivariate analyses of prognostic factors were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>77 patients underwent attempted SLNB for T4 HNM without in\u2010transit, regional, or distant metastatic disease at presentation. The mean patient age was 62 years (range, 4\u201087 years) and there was a male predominance (80%). Mean Breslow thickness was 6.1\u00a0mm (range, 4\u201021\u00a0mm). Of the 77 patients undergoing attempted SLNB, 7 had no identifiable sentinel lymph node (9%). For the remaining 91% with 1 or more identifiable sentinel lymph nodes, the mean number of nodes identified was 3.3 (range, 1\u201013). The sentinel lymph node positivity rate was 24%. A false\u2010negative SLNB occurred in 2 patients (3.8%). With a median follow\u2010up of 36\u00a0months, the estimated 5\u2010year disease\u2010free, disease\u2010specific, and overall survival rates were 47%, 74%, and 69%, respectively. A positive sentinel lymph node was significantly linked to shortened disease\u2010free survival (74 vs 36\u00a0months, <jats:italic>P<\/jats:italic> =. 026) and disease\u2010specific survival (121 vs 59\u00a0months, <jats:italic>P<\/jats:italic> =. 035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLNB provides accurate staging of the regional node basin and important prognostic information for patients with thick HNM.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815589948","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T23:32:12Z","timestamp":1434151932000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sentinel Lymph Node Biopsy Provides Prognostic Value in Thick Head and Neck Melanoma"],"prefix":"10.1002","volume":"153","author":[{"given":"Marcus M.","family":"Monroe","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Department of Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanth","family":"Pattisapu","sequence":"additional","affiliation":[{"name":"School of Medicine University of Texas at Houston Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery the University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Kupferman","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery the University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574497"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)02136-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.055"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02072.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.112346"},{"key":"e_1_2_8_7_1","first-page":"439","article-title":"The sentinel node biopsy in patients with thick melanoma: outcome analysis from a single\u2010institution database","volume":"25","author":"Covarelli P","year":"2011","journal-title":"In Vivo"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2012.04.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574479"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328355e558"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24660"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0160-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322495"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06569.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/000313480407000114","article-title":"Role of sentinel lymph node biopsy in patients with thick (>4\u00a0mm) primary melanoma","volume":"70","author":"Jacobs IA","year":"2004","journal-title":"Am Surg"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2011.01.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-40"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04109.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.04.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.115"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574492"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20875"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060992"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480807401021"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3160-x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812444268"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811411878"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26288"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.06.007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000093"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815589948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599815589948","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815589948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:11:17Z","timestamp":1760969477000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599815589948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1177\/0194599815589948"],"URL":"https:\/\/doi.org\/10.1177\/0194599815589948","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]},"assertion":[{"value":"2014-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}