{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:31:00Z","timestamp":1781886660795,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the diagnostic performance of shear wave elastography (SWE) in the differentiation of malignant and benign thyroid nodules with coexistent Hashimoto\u2019s thyroiditis (HT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary general hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>From September 2012 to January 2014, conventional ultrasound and SWE were performed on 243 patients with 286 thyroid nodules with histologic results. The HT group consisted of 93 patients with 117\u00a0nodules. The non\u2010HT group consisted of 140 patients with 169\u00a0nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the benign and malignant nodules, there were no significant differences of the mean, minimum, or maximum SWE values between HT and non\u2010HT groups (<jats:italic>P<\/jats:italic> =. 158\u2010.945). However, SWE values of extranodular tissue were significantly higher in the HT group (<jats:italic>P<\/jats:italic> =. 000\u2010.011). In the HT group, the maximum SWE value showed the highest area under the receiver operating characteristic curve (0.817; 95% confidence interval,. 735\u2010.900), and there were no significant differences when compared with other SWE parameters (<jats:italic>P<\/jats:italic> =. 669\u2010.848). In the multivariate analysis, hypoechogenicity (odds ratio = 9.855, <jats:italic>P<\/jats:italic> =. 002), microcalcification (odds ratio = 3.977, <jats:italic>P<\/jats:italic> =. 046), and maximum SWE value (odds ratio = 40.712, <jats:italic>P<\/jats:italic> &lt;. 001) were independent predictors of thyroid malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SWE could be performed to obtain a differential diagnosis between malignant and benign thyroid nodules, including nodules with coexistent HT. Although all the SWE parameters within a 2\u2010mm region of interest that was placed on the stiffest region could be applied, we suggest that the maximum value of nodules harbored within a Hashimoto\u2019s gland be used.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815600149","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T22:33:57Z","timestamp":1440542037000},"page":"779-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Shear Wave Elastography in the Diagnosis of Thyroid Nodules with Coexistent Chronic Autoimmune Hashimoto\u2019s Thyroiditis"],"prefix":"10.1002","volume":"153","author":[{"given":"Baoxian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics Institute of Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat\u2010sen University Sun Yat\u2010Sen University Guangzhou 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