{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:05:38Z","timestamp":1792641938113,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["U24 DC011968\u201001"],"award-info":[{"award-number":["U24 DC011968\u201001"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Dizziness associated with vestibular schwannoma is usually ascribed to retrolabyrinthine mechanisms. The goal of this study was to determine if quantitative peripheral vestibular (labyrinthine) otopathology was present in a series of patients with vestibular schwannoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Comparative human temporal bone study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Otopathology laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Temporal bones from 12 subjects with unilateral sporadic vestibular schwannoma were included. Based on differential interference contrast microscopy, type I and II vestibular hair cell counts were performed on each vestibular sense organ with minimal autolysis in which the neuroepithelium was oriented perpendicular to the plane of section. Hair cell densities (cells per 0.01\u2010mm<jats:sup>2<\/jats:sup> surface area) and the presence of endolymphatic hydrops and precipitate within the endolymph or perilymph were compared between the tumor ears and the contralateral (control) ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the contralateral ears, vestibular schwannoma ears had significantly more endolymphatic hydrops (<jats:italic>P<\/jats:italic> =. 049) and precipitate in the endolymph and perilymph (<jats:italic>P<\/jats:italic> =. 005), lower densities of type I and II vestibular hair cells in the lateral canal cristae (mean differences, respectively: 25.2 [<jats:italic>P<\/jats:italic> =. 001] and 10.8 [<jats:italic>P<\/jats:italic> &lt;. 001]) and utricle (mean differences, respectively: 26.8 and 10.4 [<jats:italic>P<\/jats:italic> &lt;. 001]), and lower densities of type I hair cells and the same density of type II hair cells in the saccule (mean differences, respectively: 26.5 [<jats:italic>P<\/jats:italic> &lt;. 001] and 0.9 [<jats:italic>P<\/jats:italic> =. 46]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peripheral vestibular otopathology, manifested as reductions of vestibular hair cell densities, was identified in ears with vestibular schwannoma. Labyrinthine as well as retrolabyrinthine pathology may contribute to tumor\u2010related vestibular dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815601070","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T22:33:57Z","timestamp":1440542037000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma"],"prefix":"10.1002","volume":"154","author":[{"given":"\u00d6mer","family":"H\u0131zl\u0131","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"},{"name":"Giresun A. Ilhan Ozdemir State Hospital Giresun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"},{"name":"Gebze Fatih State Hospital Gebze Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Schachern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Paparella Ear Head and Neck Institute Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000668"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.08.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.JNS14594"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219838.80931.6B"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181e8c7cb"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760050027006"},{"key":"e_1_2_8_8_1","first-page":"477","volume-title":"Schuknecht\u2019s Pathology of the Ear","author":"Merchant SN","year":"2010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e31815c2a85"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760040127002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500305"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00456332"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201111"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318248ee02"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1966.00760030397003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr200346q"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00004"},{"key":"e_1_2_8_18_1","first-page":"1","article-title":"Studies on the structure and innervation of the sensory epithelium of the cristae ampulares in the guinea pig; 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