{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:30:58Z","timestamp":1785760258732,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are a group of tumors that arise from peripheral nerves or from the various elements of the nerve sheath, including Schwann cells and perineural fibroblasts. Head and neck MPNSTs (HN\u2010MPNSTs) are rare, accounting for 8% to 16% of all soft tissue sarcomas. This study analyzes the demographic, clinicopathologic, and survival characteristics of HN\u2010MPNSTs and establishes comparisons with MPNSTs at other body sites (other\u2010MPNSTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Analysis of population\u2010based tumor registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The SEER database (Surveillance, Epidemiology, and End Results; 1973\u20102012) was queried for HN\u2010MPNSTs (324 cases) and other\u2010MPNSTs (1680 cases). Data were analyzed comparatively with respect to various demographic and clinicopathologic factors. Disease\u2010specific survival was analyzed with the Kaplan\u2010Meier model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age at diagnosis for HN\u2010MPNST was 49.1 years, compared with 46.1 years for other\u2010MPNSTs (<jats:italic>P<\/jats:italic> =. 0169). There was a sex predilection for males in HN\u2010MPNSTs (60.2%) versus a female predilection for other\u2010MPNSTs (54.2%; <jats:italic>P<\/jats:italic> &lt;. 0001). Average tumor size for HN\u2010MPNSTs was 4.9\u00a0cm, compared with 8.7\u00a0cm for other\u2010MPNSTs (<jats:italic>P<\/jats:italic> &lt;. 0001). HN\u2010MPNSTs were more commonly of low histologic grade types, whereas other\u2010MPNSTs were mostly of high histologic grade (<jats:italic>P<\/jats:italic> =. 0073). HN\u2010MPNSTs had a higher 5\u2010year disease\u2010specific survival than other\u2010MPNSTs (65.1% vs 57.4%; <jats:italic>P<\/jats:italic> =. 0209).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HN\u2010MPNSTs are rare entities. This study represents the largest series of HN\u2010MPNSTs to date. Although HN\u2010MPNSTs and other\u2010MPNSTs share a common histology, there are important clinical differences between the 2\u00a0groups.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815606700","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T20:42:52Z","timestamp":1443213772000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Comparative Analysis of Head and Neck and Non\u2013Head and Neck Malignant Peripheral Nerve Sheath Tumors"],"prefix":"10.1002","volume":"154","author":[{"given":"Tapan D.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Shaigany","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199110000-00003"},{"key":"e_1_2_8_3_1","first-page":"368920","article-title":"Malignant peripheral nerve sheath tumors of the head and neck: a case series and 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