{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:20Z","timestamp":1787018720350,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic value of non\u2013echo planar diffusion\u2010weighted magnetic resonance imaging (DW\u2010MRI) for primary and recurrent\/residual (postoperative) cholesteatoma in adults (\u226518 years) after canal wall up surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We conducted a systematic search in PubMed, Embase, and Cochrane up to October 22, 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review methods<\/jats:title>\n                    <jats:p>All studies investigating non\u2013echo planar DW\u2010MRI for primary and postoperative cholesteatoma were selected and critically appraised for relevance and validity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 779 unique articles were identified, of which 23 articles were included for critical appraisal. Seven articles met our criteria for relevance and validity for postoperative cholesteatoma. Four studies were additionally included for subgroup analysis of primary cases only. Ranges of sensitivity, specificity, positive predictive value, and negative predictive value yielded 43%\u201092%, 58%\u2010100%, 50%\u2010100% and 64%\u2010100%, respectively. Results for primary subgroup analysis were 83%\u2010100%, 50%\u2010100%, 85%\u2010100%, and 50%\u2010100%, respectively. Results for subgroup analysis for only postoperative cases yielded 80%\u201082%, 90%\u2010100%, 96%\u2010100%, 64%\u201085%, respectively. Despite a higher prevalence of cholesteatoma in the primary cases, there was no clinical difference in added value of DW\u2010MRI between primary and postoperative cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a high predictive value of non\u2013echo planar DW\u2010MRI for the detection of primary and postoperative cholesteatoma. Given the moderate quality of evidence, we strongly recommend both the use of non\u2010echo planar DW\u2010MRI scans for the follow\u2010up after cholesteatoma surgery, and when the correct diagnosis is questioned in primary preoperative cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599815613073","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T22:33:42Z","timestamp":1446503622000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A Systematic Review of Non\u2010Echo Planar Diffusion\u2010Weighted Magnetic Resonance Imaging for Detection of Primary and Postoperative Cholesteatoma"],"prefix":"10.1002","volume":"154","author":[{"given":"Sylvia L.","family":"van Egmond","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head &amp; Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Rudolf Magnus Institute of Neuroscience Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Stegeman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head &amp; Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Rudolf Magnus Institute of Neuroscience Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Grolman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head &amp; Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Rudolf Magnus Institute of Neuroscience Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C. J.","family":"Aarts","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head &amp; Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Jeroen Bosch Hospital \u2019s\u2010Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.03.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1428-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2013.08.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3952"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0360-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365931"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002197"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02332.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818edf4a"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2012.02502.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091140"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1706-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2012.02377.x"},{"key":"e_1_2_8_16_1","first-page":"197","article-title":"Value of non echo\u2010planar diffusion\u2010weighted magnetic resonance imaging in the detection of middle ear cholesteatomea","volume":"2008","author":"Nagai N","journal-title":"Mediterr J Otol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.02.021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000234"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114001418"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130065"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2824"},{"key":"e_1_2_8_22_1","first-page":"153","article-title":"HASTE diffusion\u2010weighted MRI for the reliable detection of cholesteatoma","volume":"18","author":"Ilica AT","year":"2012","journal-title":"Diagn Interv Radiol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2012.05.002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2011.02.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181dbb7c2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1352"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2381041649"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31822e938d"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346140"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813489521"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815613073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599815613073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815613073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:54:06Z","timestamp":1760964846000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599815613073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0194599815613073"],"URL":"https:\/\/doi.org\/10.1177\/0194599815613073","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]},"assertion":[{"value":"2015-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}