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Few clinical reports have described this phenomenon and its consequent effects on central auditory processing. We aim to (1) define the concept of amblyaudia and (2) review contemporary research on its pathophysiology and emerging clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Embase, and Cochrane databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A systematic literature search was performed with combinations of search terms: \u201camblyaudia,\u201d \u201cconductive hearing loss,\u201d \u201csensorineural hearing loss,\u201d \u201casymmetric,\u201d \u201cpediatric,\u201d \u201cauditory deprivation,\u201d and \u201cauditory development.\u201d Relevant articles were considered for inclusion, including basic and clinical studies, case series, and major reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During critical periods of infant brain development, imbalanced auditory input associated with AHL may lead to abnormalities in binaural processing. Patients with amblyaudia can demonstrate long\u2010term deficits in auditory perception even with correction or resolution of AHL. The greatest impact is in sound localization and hearing in noisy environments, both of which rely on bilateral auditory cues. Diagnosis and quantification of amblyaudia remain controversial and poorly defined. Prevention of amblyaudia may be possible through early identification and timely management of reversible causes of AHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Practice<\/jats:title><jats:p>Otolaryngologists, audiologists, and pediatricians should be aware of emerging data supporting amblyaudia as a diagnostic entity and be cognizant of the potential for lasting consequences of AHL. Prevention of long\u2010term auditory deficits may be possible through rapid identification and correction.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815615871","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T20:58:26Z","timestamp":1447189106000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Amblyaudia"],"prefix":"10.1002","volume":"154","author":[{"given":"Alyson B.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott D.","family":"Kozin","sequence":"additional","affiliation":[{"name":"Department of Otology and Laryngology Harvard Medical School Boston 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