{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:19:11Z","timestamp":1761394751274,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary neoplasms originating in the frontal sinus are rare. As such, existing literature describing frontal sinus malignancies (a subset of frontal sinus neoplasms) is limited. Prognostic implications of these malignancies are difficult to determine. This study seeks to analyze trends in epidemiology, clinicopathology, incidence, and survival for these rare malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SEER 18 database (Surveillance, Epidemiology, and End Results; 1973\u20102012) was searched for frontal sinus malignancies from 1973 to 2012 and analyzed for demographic and clinicopathologic trends. The Kaplan\u2010Meier model was utilized for survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 171 cases of frontal sinus malignancies were identified. Incidence was 0.011 per 100,000\u00a0individuals. The mean age at diagnosis was 61.1 years, with males constituting the majority of cases (61.4%). 80.1% of patients were white, 9.4% Asian, and 8.2% black. The average tumor size was 3.8\u00a0cm. The most common histology encountered was squamous cell carcinoma (39.8%). Overall 5\u2010year disease\u2010specific survival was 44.2%. Five\u2010year disease\u2010specific survival was highest for mature B\u2010cell non\u2010Hodgkin\u2019s lymphomas (72.3%) and lowest for adenocarcinomas (15.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Malignant tumors of the frontal sinus are rare and are more common in males. Squamous cell carcinoma is the most common entity encountered. Of the 4\u00a0most common histologies, survival is best for mature B\u2010cell non\u2010Hodgkin\u2019s lymphomas and worst for adenocarcinomas.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599815621878","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T23:45:02Z","timestamp":1450914302000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Frontal Sinus Malignancies"],"prefix":"10.1002","volume":"154","author":[{"given":"Amit","family":"Bhojwani","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Facial Plastic Surgery Rowan University School of Osteopathic Medicine Stratford New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Facial Plastic Surgery Rowan University School of Osteopathic Medicine Stratford New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pariket M.","family":"Dubal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen A.","family":"Echanique","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25465"},{"key":"e_1_2_8_3_1","first-page":"161","article-title":"Polype foungeux du sinus frontal droit","volume":"1","author":"Abernethy J","year":"1829","journal-title":"La Clinique"},{"key":"e_1_2_8_4_1","first-page":"253","article-title":"Carcinoma sinus frontalis","volume":"24","author":"Prawssud N","year":"1907","journal-title":"Vestnik Oftalmologii"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802000000400009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0491-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131008901003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.04.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70311-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.06.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00195.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109001022"},{"key":"e_1_2_8_13_1","first-page":"86","article-title":"Sino\u2010nasal adenocarcinoma: epidemiological and clinico\u2010pathological study of 34 cases","volume":"22","author":"Nunez F","year":"1993","journal-title":"J Otolaryngol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.07.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109001016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.49.481"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206070621"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2032"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197101000-00007"},{"first-page":"165","volume-title":"The Frontal Sinus","author":"Gourin CG","key":"e_1_2_8_22_1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869709100731"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"87","article-title":"Cancer of the nasal vestibule, nasal cavity and paranasal sinuses","author":"Daele JJ","year":"2005","journal-title":"B\u2010Ent"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170207"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011215)92:12<3012::AID-CNCR10131>3.0.CO;2-E"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10358"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<97::AID-HED1>3.0.CO;2-Y"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.07.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2015.08.015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25111"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1839-9"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815621878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599815621878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599815621878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:38:15Z","timestamp":1760967495000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599815621878"}},"subtitle":["A Population\u2010Based Analysis of Incidence and Survival"],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1177\/0194599815621878"],"URL":"https:\/\/doi.org\/10.1177\/0194599815621878","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2015,12,23]]},"assertion":[{"value":"2015-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}