{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:05:09Z","timestamp":1763809509452,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Understand real\u2010world prescription patterns for patients presenting with a first diagnosis of ARS and evaluate adherence to published medical guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective administrative database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>US\u2010based outpatient settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a US claims database (MarketScan), 99,033 patients were identified with acute rhinosinusitis (ARS) in 2012 (\u201cindex\u201d), with a complete medical and prescription history for 12\u00a0months preindex and 18\u00a0months postindex and no diagnoses of asthma or chronic rhinosinusitis. Of these, a random 10,000\u2010patient sample was generated matched for age and sex to the initial cohort. Prescriptions and procedures at index, as well as complications up to 12\u00a0months postindex, were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly 90% of all patients received a prescription at index. Antibiotics were prescribed for 84.8% patients, followed by antitussives (16.2% for adults, 6.2% for pediatrics), nasal corticosteroids (15.5% adults, 7.5% for pediatrics), and systemic corticosteroids (10.3% for adults, 5.5% for pediatrics), with 49% adults and 29% children receiving &gt;1\u00a0medication at first visit. Macrolides were the most frequently prescribed antibiotics (35.6% adults, 28.6% pediatrics), followed by amoxicillin\/clavulanate and amoxicillin. Within 12\u00a0months of index, 3 patients presented with meningitis and 3 with orbital cellulitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant variability in ARS treatment was observed, highlighting the need for heightened awareness of existing guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816630310","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T22:13:59Z","timestamp":1456870439000},"page":"957-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acute Rhinosinusitis"],"prefix":"10.1002","volume":"154","author":[{"given":"Michael S.","family":"Benninger","sequence":"first","affiliation":[{"name":"The Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal E.","family":"Holy","sequence":"additional","affiliation":[{"name":"Acclarent Menlo Park California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas K.","family":"Trask","sequence":"additional","affiliation":[{"name":"The Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.798"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540410020857"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"475","article-title":"Guideline for the management of upper respiratory tract infections","volume":"94","author":"Brink AJ","year":"2004","journal-title":"S Afr Med J"},{"key":"e_1_2_8_5_1","first-page":"2","article-title":"Medical management of acute bacterial sinusitis: recommendations of a clinical advisory committee on pediatric and adult sinusitis","volume":"182","author":"Brooks I","year":"2000","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis370"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"147","article-title":"Guidelines for the diagnosis and treatment of acute and subacute rhinosinusitis in children","volume":"20","author":"Esposito S","year":"2008","journal-title":"J Chem"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.115.800"},{"key":"e_1_2_8_9_1","first-page":"484","article-title":"Consensus guidelines for the management of upper respiratory tract infections [in Spanish]","volume":"72","author":"Lopardo G","year":"2012","journal-title":"Medicina"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02889.x"},{"key":"e_1_2_8_13_1","first-page":"190","article-title":"Ministry of Health clinical practice guidelines: management of rhinosinusitis and allergic rhinitis","volume":"51","author":"Siow JK","year":"2010","journal-title":"Singapore Med J"},{"key":"e_1_2_8_14_1","first-page":"S99","article-title":"Canadian clinical practice guidelines for acute and chronic rhinosinusitis","volume":"40","author":"Desrosiers M","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1071"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23980"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2012-101149"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.032"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2538"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0904266"},{"key":"e_1_2_8_23_1","first-page":"A4356","article-title":"Macrolide overuse for treatment of respiratory tract infections in general practice","volume":"58","author":"Hinnerskov M","year":"2011","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_24_1","first-page":"811","article-title":"Sinusitis in the pediatric population: American College of Radiology. 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