{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:18:31Z","timestamp":1779293911233,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical, demographic, and prognostic features of salivary gland mucinous adenocarcinoma, a rare head and neck malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Population\u2010based national cancer registry analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A review was performed with the National Cancer Database from 1998 to 2012. Demographic, clinical, and survival characteristics were compiled and analyzed. Cox multivariate regression was used to identify predictors of survival. Log\u2010rank tests were used to test survival differences unless otherwise specified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 170 cases were identified. The most common site of involvement was the parotid gland. Rates of nodal and distant metastases were 45.9% and 10.6%, respectively. High histologic grade was associated with nodal disease (<jats:italic>P<\/jats:italic> &lt;. 001) and advanced\u2010stage disease (<jats:italic>P<\/jats:italic> =. 006). Overall 5\u2010 and 10\u2010year survival rates were 60% and 44%, respectively. Multivariate analysis found tumor size \u22652\u00a0cm (hazard ratio, 22.6; 95% confidence interval: 4.06\u2010126.09; <jats:italic>P<\/jats:italic> &lt;. 001) and distant metastases (hazard ratio, 17.6; 95% confidence interval: 3.75\u201082.68; <jats:italic>P<\/jats:italic> &lt;. 001) to predict poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mucinous adenocarcinoma of the salivary gland is a rare otolaryngic cancer. Regional metastases and advanced stage are more common with high histologic grade. Tumor size and distant metastases negatively influence survival.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816630546","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T22:43:55Z","timestamp":1456267435000},"page":"875-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mucinous Adenocarcinoma of the Salivary Gland"],"prefix":"10.1002","volume":"154","author":[{"given":"Zachary","family":"Farhood","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Y.","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Lentsch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.04.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0699-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.10.016"},{"key":"e_1_2_9_5_1","volume-title":"World Health Organization Classification of Tumors: Pathology and Genetics of the Head and Neck Tumors","author":"Barnes L","year":"2005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2014.11.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00271-5"},{"key":"e_1_2_9_8_1","volume-title":"Atlas of Head and Neck Pathology","author":"Wenig BM","year":"2008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1100::AID-CNCR2820360339>3.0.CO;2-R"},{"key":"e_1_2_9_10_1","volume-title":"World Health Organization Classification of Tumours: Tumours of the Digestive System","author":"Hamilton SR","year":"2000"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159104.02985.6b"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e318202645a"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00458.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7920.1000126"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.126698"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2013.39342"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816630546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599816630546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816630546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:15:50Z","timestamp":1760969750000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599816630546"}},"subtitle":["A Review of a Rare Tumor"],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/0194599816630546"],"URL":"https:\/\/doi.org\/10.1177\/0194599816630546","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"2015-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}