{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:31Z","timestamp":1761006931520,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>When total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment options are available for early and advanced glottic cancers due to equivalent locoregional control and survival rates. However, in today\u2019s climate of accountable care, the financial burden of treatment choices continues to increase in significance. We therefore compared hospital charges and treatment\u2010related morbidity between organ\u2010preserving surgery and radiation with or without chemotherapy\u2014herein, <jats:italic>(chemo)radiation<\/jats:italic>\u2014in the primary treatment of glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Nationwide Inpatient Sample Database was analyzed to assess clinical and financial information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Population\u2010based analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Patients (N = 5499) with primary glottic cancer undergoing treatment with laryngeal preservation strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were subdivided by <jats:italic>ICD\u20109<\/jats:italic> codes into 3 treatment groups: endoscopic resection, open partial laryngectomy, and (chemo)radiation. Treatment\u2010related outcomes, charges, and length of hospitalization were analyzed among treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When adjusting for sex, age, race, comorbidity, and primary payer, (chemo)radiotherapy was associated with increased direct charges (<jats:italic>P<\/jats:italic> &lt;. 001; coefficient, $23,658.99; 95% confidence interval [95% CI]: $10,227.15\u2010$37,090.84) and length of hospitalization (<jats:italic>P<\/jats:italic> &lt;. 001; hazard ratio, 0.593; 95% CI: 0.502\u20100.702) when compared with endoscopic surgery. As compared with open surgery, endoscopic surgery was associated with reduced hospital charges (<jats:italic>P<\/jats:italic> =. 012; coefficient, $11,967.01; 95% CI: $2,784.17\u2010$21,249.85) and duration of hospitalization (<jats:italic>P<\/jats:italic> &lt;. 001; hazard ratio, 0.749; 95% CI: 0.641\u20100.876).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis suggests that increased utilization of endoscopic surgery in patients with primary glottic cancer not requiring total laryngectomy may lead to reduced financial burden and duration of hospitalization when compared with open surgery or (chemo)radiation therapy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816639248","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T21:29:35Z","timestamp":1459286975000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Laryngeal Preservation in Glottic Cancer"],"prefix":"10.1002","volume":"155","author":[{"given":"Rachel S.","family":"Mandelbaum","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California\u2013Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Abemayor","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California\u2013Los Angeles Los Angeles California USA"},{"name":"Jonsson Comprehensive Cancer Center David Geffen School of Medicine at the University of California\u2013Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abie H.","family":"Mendelsohn","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California\u2013Los Angeles Los Angeles California USA"},{"name":"Jonsson Comprehensive Cancer Center David Geffen School of Medicine at the University of California\u2013Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"first-page":"43","volume-title":"Functional Preservation and Quality of Life in Head and Neck Radiotherapy","author":"Mendenhall WM","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23724"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.171"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4559"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3280147336"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1028-2"},{"key":"e_1_2_8_10_1","first-page":"603","article-title":"Treatment of early\u2010stage glottic cancer: meta\u2010analysis comparison of laser excision versus radiotherapy","volume":"38","author":"Higgins KM","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1237"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800605"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1270"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21294"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21226"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300104"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000156168.63204.70"},{"key":"e_1_2_8_18_1","unstructured":"Healthcare Cost and Utilization Project.Overview of the Nationwide Inpatient Sample.http:\/\/www.hcup\u2010us.ahrq.gov\/nisoverview.jsp. 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