{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:20Z","timestamp":1787018720366,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Hypothesis<\/jats:title>\n                    <jats:p>The aim of this population\u2010based study is to analyze the survival benefits of elective neck dissection (END) over neck observation in T1\/T2N0M0 oral tongue squamous cell carcinoma (OT\u2010SCC) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective administrative database analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>The SEER database (Surveillance, Epidemiology, and End Results) was queried for patients diagnosed with T1\/T2N0M0 OT\u2010SCC from 1998 to 2011. Data included patient demographics, initial treatment, and survival outcomes. The Kaplan\u2010Meier model and the Cox proportional hazards model were utilized for survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 7010 T1\/T2N0M0 cases, END was performed in 1770 T1 and 950 T2 cases, and the neck was observed in 3278 T1 and 1001 T2 cases. Significantly poorer 5\u2010year disease\u2010specific survival (DSS) rates were noted for the neck observation group when compared with the END group for tumors with moderately differentiated (72.1% vs 86%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 0001) and poorly differentiated or undifferentiated (55.6% vs 71.5%,\n                      <jats:italic>P<\/jats:italic>\n                      =. 0001) histologic grades. No significant survival benefit was seen between the END group and the neck observation group when tumor size was &lt;1\u00a0cm, regardless of histology grade. However, those with tumors &gt;1\u00a0cm had a significantly better 5\u2010year DSS with END, except for the well\u2010differentiated tumor cohort, which showed improved survival only when the tumors were &gt;2\u00a0cm (5\u2010year DSS: END vs neck observation, 83.5% vs 65.7%,\n                      <jats:italic>P<\/jats:italic>\n                      =. 0002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>END improves DSS versus neck observation in T1\/T2N0M0 OT\u2010SCC patients with moderately differentiated, poorly differentiated, or undifferentiated histologic grade tumors &gt;1\u00a0cm. Those with well\u2010differentiated tumors benefited from END only when tumor size was &gt;2\u00a0cm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599816643695","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T23:24:49Z","timestamp":1462922689000},"page":"588-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of Elective Neck Dissection in T1\/T2N0M0 Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"155","author":[{"given":"Tapan D.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical 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Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Chan Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey 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