{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:22:08Z","timestamp":1789690928674,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["U24 DC011968\u201001"],"award-info":[{"award-number":["U24 DC011968\u201001"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001873","name":"Starkey Hearing Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Comparative human temporal bone study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We compared 23 temporal bone specimens from 19 deceased donors with LO associated with the round window membrane (RWM) and 27 age\u2010matched specimens from 20 deceased donors without any otologic diseases. We focused on the location of LO in the inner ear, the intensity of endolymphatic hydrops, the number of spiral ganglion cells and cochlear hair cells, and the areas of the stria vascularis and spiral ligament. In addition, we created a new pathologic grading system for temporal bone specimens from deceased donors with LO associated with the RWM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We most often observed LO in the scala tympani of the basal cochlear turn. In the LO group (as compared with the control group), the intensity of endolymphatic hydrops was significantly increased; the number of spiral ganglion cells was significantly decreased in all segments; the loss of outer and inner hair cells was significantly increased in all turns of the cochlea; the atrophy of the stria vascularis was significantly greater in all turns of the cochlea; and atrophy of the spiral ligament was significantly greater in the basal and middle cochlear turn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LO was associated with significant cochlear damage (to the spiral ganglion cells, cochlear hair cells, stria vascularis, and spiral ligament) and with increased intensity of endolymphatic hydrops.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816651245","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T21:51:43Z","timestamp":1464126703000},"page":"635-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane"],"prefix":"10.1002","volume":"155","author":[{"given":"Serdar","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Gebze Fatih State Hospital Gebze Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Paparella Ear Head &amp; Neck Institute Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600303"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1286-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100116846"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197808000-00004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790310054014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198308000-00006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400306"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909800602"},{"key":"e_1_2_8_13_1","first-page":"3","article-title":"Ganglion cell populations in labyrinthitis ossificans","volume":"12","author":"Hinojosa R","year":"1991","journal-title":"Am J Otol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800290024005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000904"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400214"},{"key":"e_1_2_8_17_1","first-page":"74","article-title":"Pathology of prelingual profound deafness: magnitude of labyrinthitis fibro\u2010ossificans","volume":"15","author":"Lu CB","year":"1994","journal-title":"Am J Otol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00325.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816651245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599816651245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816651245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:27:21Z","timestamp":1760952441000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599816651245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/0194599816651245"],"URL":"https:\/\/doi.org\/10.1177\/0194599816651245","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]},"assertion":[{"value":"2016-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}