{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:25:09Z","timestamp":1767651909351,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the feasibility and tolerability of a steroid\u2010eluting middle ear device on an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective experimental.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Experimental animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Method<\/jats:title><jats:p>Mometasone furoate (MF)\u2013eluting miniature sticks were implanted through a myringotomy incision into the middle ear of 10 guinea pigs. Two additional ears of 2 animals served as controls. Fourteen days after implantation, perilymphatic fluid was collected through an endaural cochleostomy. MF concentrations were measured with high\u2010performance liquid chromatography, and the middle ear mucosal inflammation was graded with hematoxylin and eosin colorations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen days after implantation, all tympanic membranes had fully healed. An average of 165\u00a0ng\/mL of MF was detected in the perilymphatic fluid of the experimental ears, and none was measured in control ears. Microscopic residues of the ministicks were found in 90% of the samples, confirming the bioabsorbable properties of this device. Histologic analysis of the middle ear mucosa found similar inflammation profiles in both groups, thereby suggesting middle ear tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MF\u2010coated bioabsorbable miniature stick allows for prolonged delivery over 14\u00a0days without injuring the middle ear mucosa. Middle ear\u2013sustained steroid delivery may prove to be beneficial in numerous neurotologic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816651262","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T21:51:43Z","timestamp":1464126703000},"page":"649-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sustained Inner Ear Steroid Delivery via Bioabsorbable Stent"],"prefix":"10.1002","volume":"155","author":[{"given":"Philippe","family":"Lavigne","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Montreal University Hospital Center University of Montreal Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Montreal University Hospital Center University of Montreal Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam","family":"Saliba","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Montreal University Hospital Center University of Montreal Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32830e20db"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318263d35d"},{"key":"e_1_2_8_4_1","first-page":"196","article-title":"Dexamethasone inner ear perfusion for the treatment of M\u00e9ni\u00e8re\u2019s disease: a prospective, randomized, double\u2010blind, crossover trial","volume":"19","author":"Silverstein H","year":"1998","journal-title":"Am J Otol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000235310.72442.4e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000434"},{"key":"e_1_2_8_7_1","first-page":"75","article-title":"Mometasone implant for chronic rhinosinusitis","volume":"5","author":"Wei CC","year":"2012","journal-title":"Med Devices (Auckl)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3391"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.10.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410022534"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32830ce796"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812436449"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812464475"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00138-2"},{"key":"e_1_2_8_16_1","article-title":"Intratympanic corticosteroids injections: a systematic review of literature","author":"Lavigne P","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_8_17_1","first-page":"CD008514","article-title":"Intratympanic steroids for M\u00e9ni\u00e8re\u2019s disease or syndrome","volume":"7","author":"Phillips JS","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345208"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000753"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20074"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816651262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599816651262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816651262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:27:17Z","timestamp":1760952437000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599816651262"}},"subtitle":["A Tolerability and Feasibility Study on Guinea Pigs"],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/0194599816651262"],"URL":"https:\/\/doi.org\/10.1177\/0194599816651262","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2016,7,22]]},"assertion":[{"value":"2016-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}