{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:10:55Z","timestamp":1783476655860,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Persistent dysphonia from vocal fold scar remains a clinical challenge, with current therapies providing inconsistent outcomes. We evaluated voice outcomes after a single office\u2010based steroid injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This study was based on pre\u2010 and postoperative analysis of patient\u2010reported, perceptual, acoustic, aerodynamic, and videostroboscopic parameters. The sample comprised 25 patients undergoing office\u2010based dexamethasone injection into the superficial lamina propria for mild\/moderate vocal fold scar. Average follow\u2010up was 13.7 \u00b1 4.4 weeks; patients completed 3.5 \u00b1 2.3 sessions of voice therapy between assessments. Complete data sets were not available for each parameter; sample size is noted with results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Voice handicap index (n = 24; <jats:italic>P<\/jats:italic> &lt;. 001) and glottal function index (n = 22; <jats:italic>P<\/jats:italic> &lt;. 001) decreased after injection. Total GRBAS score (grade, roughness, breathiness, asthenia, strain) decreased (n = 25; <jats:italic>P<\/jats:italic> &lt;. 001). Fundamental frequency range increased (n = 24; <jats:italic>P<\/jats:italic> =. 024). Phonation threshold pressure decreased (n = 14; <jats:italic>P<\/jats:italic> =. 017). Videostroboscopic parameters of vocal fold edge (<jats:italic>P<\/jats:italic> =. 004), glottic closure (<jats:italic>P<\/jats:italic> =. 003), and right mucosal wave (<jats:italic>P<\/jats:italic> =. 016) improved after injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Office\u2010based steroid injection combined with voice therapy for mild\/moderate vocal fold scar is associated with improved patient\u2010reported and functional voice measures. These findings provide preliminary support for this approach. Importantly, the procedure is low risk and can be performed in the office, thus offering a simple treatment alternative to patients with a disorder that has traditionally been difficult to manage. Prospective studies evaluating the effects of multiple injections are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816654899","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:34:21Z","timestamp":1470782061000},"page":"820-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Voice Outcomes following a Single Office\u2010Based Steroid Injection for Vocal Fold Scar"],"prefix":"10.1002","volume":"155","author":[{"given":"William G.","family":"Young","sequence":"first","affiliation":[{"name":"Proliance Eastside Ear Nose and Throat Kirkland Washington USA"},{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Koszewski","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad W.","family":"Whited","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"},{"name":"Austin Ear, Nose &amp; Throat Clinic Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brienne N.","family":"Ruel","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth H.","family":"Dailey","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989611500521"},{"key":"e_1_2_8_3_1","first-page":"239","article-title":"Phonosurgery: basic and clinical investigations","volume":"21","author":"Hirano M.","year":"1975","journal-title":"Otologia (Fukuoka)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.09.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0383"},{"key":"e_1_2_8_6_1","first-page":"475","article-title":"The physiology of wound healing","volume":"29","author":"Young A","year":"2011","journal-title":"Surgery"},{"key":"e_1_2_8_7_1","first-page":"409","article-title":"Basic science of wound healing","volume":"28","author":"Beldon P.","year":"2010","journal-title":"Surgery"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00078-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196609000-00005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90319-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-163-40750"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0720-x"},{"key":"e_1_2_8_13_1","first-page":"496","article-title":"Intracordal injection of dexamethasone","volume":"57","author":"Yanagihara N","year":"1964","journal-title":"Practica Otorhinolaryngol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231455.19183.8c"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(89)80127-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814566601"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.11.961"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2006.05.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_8_21_1","volume-title":"Clinical Examination of Voice","author":"Hirano Hirano M","year":"1981"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4303.796"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32833fe112"},{"key":"e_1_2_8_24_1","article-title":"The risk of vocal fold atrophy after serial corticosteroid injections of the vocal fold [published online November 24, 2015]","author":"Shi LL","journal-title":"J Voice"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.620620"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(97)80026-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.12.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2498-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2173516"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487409126379"},{"key":"e_1_2_8_31_1","first-page":"446","article-title":"Microsurgery for benign lesions of the vocal folds","volume":"67","author":"Bouchayer M","year":"1988","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(97)80083-5"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199702000-00008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100307"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32833f890d"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600108"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211101104"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.01.019"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.01.009"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282f1fbb2"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815577104"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900211"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283327d4c"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.168"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813489657"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734608320786"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196104000-00001"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816654899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599816654899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816654899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:12:21Z","timestamp":1760951541000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599816654899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,20]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1177\/0194599816654899"],"URL":"https:\/\/doi.org\/10.1177\/0194599816654899","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,20]]},"assertion":[{"value":"2015-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}