{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:08:19Z","timestamp":1793203699084,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess pretreatment levels in the counts and percentages of leukocytes and the neutrophil\u2010lymphocyte ratio (NLR) in benign and malignant salivary gland tumors (SGTs) while investigating whether NLR is an inflammatory marker for distinguishing low\u2010 from high\u2010grade parotid gland tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This study was performed on 182 patients with SGTs (age range: 16\u201087 years; 93\u00a0male and 89 female) who were treated between January 2010 and May 2015. Pretreatment counts and percentages of leukocytes and NLR were measured preoperatively in benign and malignant tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean neutrophil percentage (63.50% \u00b1 12.11% vs 58.76% \u00b1 8.20%, <jats:italic>P<\/jats:italic> =. 008) and NLR (3.29 \u00b1 3.13 vs 2.13 \u00b1 1.26, <jats:italic>P<\/jats:italic> =. 008) were significantly higher in patients with malignant SGTs than in patients with benign SGTs. Mean lymphocyte count (2.42 \u00b1 0.72 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup> vs 1.97 \u00b1 0.87 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt;. 001) and percentage (30.67% \u00b1 7.68% vs 26.86% \u00b1 10.15%, <jats:italic>P<\/jats:italic> =. 011) were lower in patients with malignant SGTs than in patients with benign SGTs. Mean lymphocyte percentage and NLR were significantly different between low\u2010 and high\u2010grade malignant parotid gland tumors (<jats:italic>P<\/jats:italic> =. 026 and <jats:italic>P<\/jats:italic> =. 030, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated NLR could be an inflammatory marker to distinguish low\u2010 from high\u2010grade malignant parotid gland tumors.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816659257","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T21:38:11Z","timestamp":1468964291000},"page":"988-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Pretreatment Neutrophil\u2010Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy"],"prefix":"10.1002","volume":"155","author":[{"given":"Murat","family":"Damar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Faculty of Medicine B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykut Erdem","family":"Din\u00e7","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Faculty of Medicine B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Faculty of Medicine B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Aydil","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Faculty of Medicine Gazi University Ankara 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