{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:40:22Z","timestamp":1760956822008,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the clinicopathologic characteristics of patients with immunoglobulin G4\u2013related chronic sclerosing sialadenitis (IgG4\u2010RCSS), a recently recognized disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review and pathology study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Tertiary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We evaluated chronic sialadenitis specimens obtained over 11 years using pathologic examination and IgG4 immunohistochemistry staining. The specimens were assigned a revised diagnosis of IgG4\u2010RCSS or chronic sialadenitis not otherwise specified, and clinicopathologic data from each group were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 84 patients, 21 were diagnosed with IgG4\u2010RCSS and 63 with chronic sialadenitis not otherwise specified. IgG4\u2010RCSS patients were older (68.2 \u00b1 13.9 vs 54.2 \u00b1 15.8 years, <jats:italic>P<\/jats:italic> =. 001), predominantly male (85.7% vs 61.9%, <jats:italic>P<\/jats:italic> =. 036), and more likely to present with painless swelling (75% vs 44.3%, <jats:italic>P<\/jats:italic> =. 001) and bilateral involvement (52.4% vs 6.3%, <jats:italic>P<\/jats:italic> &lt;. 001). Ratio of IgG4\u2010positive plasma cells to IgG\u2010positive plasma cells in IgG4\u2010RCSS tissues was 0.81 \u00b1 0.14. The mean value of serum IgG4\u00a0in IgG4\u2010RCSS patients was 918.8\u00a0mg\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IgG4\u2010RCSS is more common in older male patients and frequently presents with bilateral involvement. Informing head and neck surgeons of the clinical features of IgG4\u2010RCSS and promoting a combined approach of clinical evaluation, imaging, and biopsy can improve the accuracy of preoperative diagnoses.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816665603","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T21:53:39Z","timestamp":1472594019000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathology of Immunoglobulin G4\u2013Related Chronic Sclerosing Sialadenitis"],"prefix":"10.1002","volume":"155","author":[{"given":"Dun\u2010Hao","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Far Eastern Memorial Hospital New Taipei City 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