{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:15:44Z","timestamp":1790820944278,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>M\u00e9ni\u00e8re\u2019s disease is an inner ear disorder characterized by vertigo attacks, fluctuating and progressive hearing loss, tinnitus, and aural fullness in the affected ear. The pathophysiology of M\u00e9ni\u00e8re\u2019s disease remains elusive. Theories so far are anatomical variation in the size or position of the endolymphatic sac and duct, viral inflammation or autoimmune involvement of the sac, or a genetically determined abnormality of endolymph control. Animal studies on blocking the ductus reuniens and endolymphatic duct have produced hydrops in the cochlea, saccule, and utricle. Cone beam computed tomography images show a similar pattern with apparent obstruction of the ductus reuniens, saccular duct, and endolymphatic sinus. New studies documenting the age of onset of M\u00e9ni\u00e8re\u2019s disease show a pattern similar to benign paroxysmal positional vertigo, raising the possibility that the fundamental cause of M\u00e9ni\u00e8re\u2019s disease might be detached saccular otoconia.<\/jats:p>","DOI":"10.1177\/0194599816675843","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T06:54:02Z","timestamp":1478674442000},"page":"350-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A New Theory for M\u00e9ni\u00e8re\u2019s Disease: Detached Saccular Otoconia"],"prefix":"10.1002","volume":"156","author":[{"given":"Jeremy","family":"Hornibrook","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Christchurch Hospital Christchurch New Zealand"},{"name":"University of Otago Christchurch New Zealand"},{"name":"University of Canterbury Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bird","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Christchurch Hospital Christchurch New Zealand"},{"name":"University of Otago Christchurch New Zealand"},{"name":"University of Canterbury Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770030767020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199209000-00006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488009127141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1974.00780030138014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318271c48b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903096648"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.680980"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1034879"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1175663"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.02.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30139-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114001972"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816675843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599816675843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599816675843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:59Z","timestamp":1760955779000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599816675843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/0194599816675843"],"URL":"https:\/\/doi.org\/10.1177\/0194599816675843","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]},"assertion":[{"value":"2016-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}