{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:42:44Z","timestamp":1767170564277,"version":"build-2238731810"},"reference-count":87,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed database of the National Library of Medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Practice<\/jats:title>\n                    <jats:p>New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599816685559","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T20:17:45Z","timestamp":1491250665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Panel 3: Genetics and Precision Medicine of Otitis Media"],"prefix":"10.1002","volume":"156","author":[{"given":"Jizhen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hena","family":"Hafr\u00e9n","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology\u2013Head and Neck Surgery Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kerschner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Communication Sciences Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Inflammation Immunity and Infection Institute for Biomedical Sciences Georgia State University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Brown","sequence":"additional","affiliation":[{"name":"Medical Research Council Harwell Institute Oxfordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing Y.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Case Western University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Preciado","sequence":"additional","affiliation":[{"name":"Shiekh Zayed Institute for Pediatric Surgical Innovation Pediatric Otolaryngology Children\u2019s National Health System Washington, DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Second Affiliated Hospital Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-001-0048-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811419468"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812455780"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182862b57"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.07.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102739"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425914526074"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24097"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402751"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112516"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2674"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0292-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.09.026"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0411-2"},{"key":"e_1_2_7_17_1","first-page":"18","volume":"15","author":"Rye MS, Scaman ES, Thornton RB, et al. 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