{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:48:40Z","timestamp":1788929320278,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the survival rate of a nonselected pyriform sinus cancer population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 122 patients were included in this study covering the 2002\u20102008 period. All patients had squamous cell carcinoma originating from the pyriform sinus. Survival and prognostic factors were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010 and 5\u2010year overall survival rates were 39.7% and 2.4%, respectively. The 3\u2010 and 5\u2010year survival rates without recurrence were 34% and 27%, respectively. The median survival rates by UICC stage were as follows: stage 1 and 2 patients, 60\u00a0months; stage 3, 40\u00a0months; stage 4, 19\u00a0months. Stage 4 patients had a lower median survival rate than other stages (<jats:italic>P<\/jats:italic> =. 039). The 5\u2010year survival rate was 46% for patients having T3\u2010T4 operable cancers treated by surgery vs 45% for patients treated by laryngeal conservation protocol (not significant). The 5\u2010year survival rate for patients having nonoperable T4 cancers was 17.2%. The 3\u2010 and 5\u2010year overall survival rates of N0 patients was significantly higher than N1 patients (<jats:italic>P<\/jats:italic> =. 042). N2 and N3 patients had 100% 5\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that overall survival and therapeutic management depend on the initial stage of pyriform sinus cancer, notably on the N status. In particular, nonoperable T4 pyriform sinus cancer and N2 and N3 patients had a very poor prognosis. A laryngeal conservation protocol seemed as effective as surgical management in terms of survival.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599816686335","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T23:33:00Z","timestamp":1484177580000},"page":"498-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic Management of Pyriform Sinus Cancer: Results of a Single\u2010Center Study of 122\u00a0Patients"],"prefix":"10.1002","volume":"156","author":[{"given":"J\u00e9r\u00f4me","family":"Donnadieu","sequence":"first","affiliation":[{"name":"ENT and Head and Neck Surgery Department University Hospital of Amiens Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Klopp\u2010Dutote","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Surgery Department University Hospital of Amiens Amiens 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