{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:09:02Z","timestamp":1793383742757,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess patient\u2010based outcomes of participants in a large cohort study\u2014the STAR trial (Stimulation Therapy for Apnea Reduction)\u201448\u00a0months after implantation with an upper airway stimulation system for moderate to severe obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A multicenter prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Industry\u2010supported multicenter academic and clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>Participants (n = 91) at 48\u00a0months from a cohort of 126 implanted participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 126 participants received an implanted upper airway stimulation system in a prospective phase III trial. Patient\u2010reported outcomes at 48\u00a0months, including Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), and snoring level, were compared with preimplantation baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 91 subjects completed the 48\u2010month visit. Daytime sleepiness as measured by ESS was significantly reduced (\n                      <jats:italic>P<\/jats:italic>\n                      =. 01), and sleep\u2010related quality of life as measured by FOSQ significantly improved (\n                      <jats:italic>P<\/jats:italic>\n                      =. 01) when compared with baseline. Soft to no snoring was reported by 85% of bed partners. Two patients required additional surgery without complication for lead malfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upper airway stimulation maintained a sustained benefit on patient\u2010reported outcomes (ESS, FOSQ, snoring) at 48\u00a0months in select patients with moderate to severe obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599817691491","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T08:01:10Z","timestamp":1487059270000},"page":"765-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Upper Airway Stimulation for Obstructive Sleep Apnea: Patient\u2010Reported Outcomes after 48\u00a0Months of Follow\u2010up"],"prefix":"10.1002","volume":"156","author":[{"given":"M. Boyd","family":"Gillespie","sequence":"first","affiliation":[{"name":"University of Tennessee Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Soose","sequence":"additional","affiliation":[{"name":"School of Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Tucker","family":"Woodson","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingman P.","family":"Strohl","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim T.","family":"Maurer","sequence":"additional","affiliation":[{"name":"University Hospital Mannheim Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"de Vries","sequence":"additional","affiliation":[{"name":"OLVG Hospital and ACTA Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Steward","sequence":"additional","affiliation":[{"name":"University of Cincinnati Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Z.","family":"Baskin","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Safwan","family":"Badr","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan A.","family":"Padhya","sequence":"additional","affiliation":[{"name":"University of South Florida College of Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mickelson","sequence":"additional","affiliation":[{"name":"Advanced ENT Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. McDowell","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of South Florida College of Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier M.","family":"Vanderveken","sequence":"additional","affiliation":[{"name":"Antwerp University Hospital Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Patrick J.","family":"Strollo","sequence":"additional","affiliation":[{"name":"School of Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the STAR Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"246","article-title":"Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort 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