{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:43:46Z","timestamp":1791330226339,"version":"4.3.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) Perform a meta\u2010analysis of the available data on the outcomes of CyberKnife radiosurgery for treatment of vestibular schwannomas (VSs) in the published English\u2010language literature and (2) evaluate the collective outcomes of CyberKnife treatment with respect to tumor control and hearing preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A thorough literature search of published English\u2010language articles was performed in the PubMed, Ovid, and Cochrane databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A database search was conducted with the keywords \u201cCyberKnife\u201d and \u201cvestibular schwannoma\u201d or \u201cacoustic neuroma.\u201d A total of 25 papers were found and reviewed. Data were extracted for patient demographics, number of patients with neurofibromatosis type 2, pretreatment hearing status, tumor size, margin dose, and follow\u2010up duration. The primary outcome variables evaluated were tumor control and hearing preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After careful review of the published articles, 11 papers reported data on outcomes of CyberKnife treatment for VS and were included in the analysis, comprising 800 patients studied during 1998 to 2012. The reported mean tumor volume ranged from 0.02 to 19.8\u00a0cm<jats:sup>3<\/jats:sup>, and the follow\u2010up duration ranged from 6 to 120\u00a0months. Margin dose varied from 14 to 25\u00a0Gy. The collective mean tumor control rate was 96.3% (95% CI: 94.0%\u201098.5%). The collective hearing preservation rate was 79.1% (95% CI: 71.0%\u201087.3%) in 427 patients with measurable hearing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical data on outcomes of CyberKnife radiosurgery for treatment of VSs are sparse and primarily limited to single\u2010institution analyses, with considerable variation in tumor volume and follow\u2010up time. This meta\u2010analysis not only provides an in\u2010depth analysis of available data in the literature but also reviews reported outcomes and complications.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599817695805","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T18:08:31Z","timestamp":1493143711000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["CyberKnife for Treatment of Vestibular Schwannoma: A Meta\u2010analysis"],"prefix":"10.1002","volume":"157","author":[{"given":"Hossein","family":"Mahboubi","sequence":"first","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Sahyouni","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"},{"name":"Department of Biomedical Engineering University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Moshtaghi","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Ghavami","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Ziai","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison W.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Djalilian","sequence":"additional","affiliation":[{"name":"Division of Neurotology and Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine California USA"},{"name":"Department of Biomedical Engineering University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"253","article-title":"First United States 201 source cobalt\u201060 gamma unit for radiosurgery","volume":"50","author":"Lunsford LD","year":"1987","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000223512.09115.3E"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099863"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000088805.01793.5A"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.38"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2006.05.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.07.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.07.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2010.09.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.1.0001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200112000-00003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-830095"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-78205-7_29"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815573223"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.10.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31821e192f"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.JNS131552"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000159650.79833.2B"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00121"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318222e451"},{"key":"e_1_2_8_24_1","first-page":"60","article-title":"A meta\u2010analysis of treatment of vestibular schwannoma using Gamma Knife radiosurgery","volume":"18","author":"Rykaczewski B","year":"2014","journal-title":"Contemp Oncol (Pozn)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10929088.2011.565160"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/297093"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt082"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343215"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182a435f5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.JNS131552"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181dbc2ab"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-002-0974-x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000801"},{"key":"e_1_2_8_35_1","first-page":"3316","volume-title":"Neurological Surgery","author":"Ojemann RG","year":"1990"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-011-0307-8"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318241c086"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219217.14930.14"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813512106"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815590105"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107001077"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181c34bda"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200606000-00018"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510038013"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00079-6"},{"key":"e_1_2_8_46_1","first-page":"851","article-title":"A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma: clinical article","volume":"119","author":"Yang I","year":"2013","journal-title":"J Neurosurg"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0703-5"},{"issue":"17","key":"e_1_2_8_48_1","first-page":"77","article-title":"Hearing outcome after gamma knife radiosurgery for vestibular schwannoma: a prospective Belgian clinical study","volume":"7","author":"Delbrouck C","year":"2011","journal-title":"B\u2010ENT"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.05.009"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20988"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817695805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599817695805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817695805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:46:26Z","timestamp":1760967986000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599817695805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/0194599817695805"],"URL":"https:\/\/doi.org\/10.1177\/0194599817695805","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]},"assertion":[{"value":"2016-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}