{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:55:33Z","timestamp":1770069333011,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) Describe longitudinal trends in annual prevalence of hospital admission for pediatric acute otitis media (AOM) and complications of AOM (CAOM) since introduction of pneumococcal vaccination in 2000 and (2) describe the longitudinal trend of prevalence of hospital admission for pneumococcal meningitis in children with AOM\u2010related diagnoses in the postvaccination era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis of Kids\u2019 Inpatient Database from 2000 to 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Community, nonrehabilitation hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>To determine annual prevalence of admission for AOM\/CAOM, nationally weighted frequencies of children aged &lt;21 years with acute suppurative otitis media, acute mastoiditis, suppurative labyrinthitis, and\/or acute petrositis were collected. The frequency of coexisting pneumococcal meningitis diagnoses among these patients was also collected. Trend analysis of prevalences of admission for AOM\/CAOM and for pneumococcal meningitis occurring in the setting of AOM\/CAOM from 2000 to 2012 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2000 and 2012, annual prevalence of admission for AOM\/CAOM decreased from 3.956 to 2.618 per 100,000 persons (<jats:italic>P<\/jats:italic> &lt;. 0001) (relative risk reduction 34%). Declines in admission prevalence were most pronounced in children &lt;1 year of age (from 22.647 to 8.715 per 100,000 persons between 2000 and 2012, <jats:italic>P<\/jats:italic> &lt;. 0001) and 1 to 2 years of age (from 13.652 to 5.554 per 100,000 persons between 2000 and 2012, <jats:italic>P<\/jats:italic> &lt;. 0001). For all ages, the admission prevalence for pneumococcal meningitis and concomitant AOM\/CAOM decreased (from 1.760 to 0.717 per 1,000,000 persons, <jats:italic>P<\/jats:italic> &lt;. 0001) over the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of hospital admission for pediatric AOM\/CAOM has declined since the advent of pneumococcal vaccination. Admission rates for pneumococcal meningitis with AOM\/CAOM have similarly declined.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599817699599","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T08:33:32Z","timestamp":1490690012000},"page":"938-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pediatric Acute Otitis Media in the Era of Pneumococcal Vaccination"],"prefix":"10.1002","volume":"156","author":[{"given":"Kareem O.","family":"Tawfik","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey L.","family":"Ishman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Divisions of Otolaryngology\u2013Head &amp; Neck Surgery and Pulmonary Medicine Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jareen","family":"Meinzen\u2010Derr","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Biostatistics and Epidemiology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel I.","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1163"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.23.3096"},{"key":"e_1_2_8_4_1","first-page":"7","article-title":"Recommended childhood immunization schedule\u2014United States, 2001","volume":"50","author":"Centers for Disease Control and Prevention (CDC)","year":"2001","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102083440602"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0619"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/429908"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181c1bc48"},{"key":"e_1_2_8_10_1","first-page":"258","article-title":"Licensure of a 13\u2010valent pneumococcal conjugate vaccine (PCV13) and recommendations for use among children\u2014Advisory Committee on Immunization Practices (ACIP), 2010","volume":"59","author":"Centers for Disease Control and Prevention (CDC)","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.3924"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31815a0001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21727"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a6adb7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112002654"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.09.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.269"},{"key":"e_1_2_8_18_1","unstructured":"US Census Bureau.Population and Housing Unit Estimates.https:\/\/www.census.gov\/programs\u2010surveys\/popest.html. Accessed December 31 2016."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.1.83"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.318"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.03.034"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3555"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0592-F"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.04.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31823dbc70"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2012.5.1.17"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221505774481219"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2011.4.3.122"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2703"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814557777"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/587897"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800836"},{"key":"e_1_2_8_33_1","first-page":"988","article-title":"National, state, and urban area vaccination coverage among children aged 19\u201035\u00a0months\u2014United States, 2005","volume":"55","author":"Centers for Disease Control and Prevention (CDC)","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1451"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1115"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.12.1608"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181faac7c"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182840fe7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1441"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0164"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2449"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000243163.85163.a8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62225-8"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817699599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599817699599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599817699599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:54Z","timestamp":1760955654000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599817699599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0194599817699599"],"URL":"https:\/\/doi.org\/10.1177\/0194599817699599","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]},"assertion":[{"value":"2016-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}